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Rosmarinic acid inhibits the formation of reactive oxygen and nitrogen species in RAW264.7 macrophages
TLDR
Ros A can act as an effective protector against peroxynitrite-mediated damage, and as a potent inhibitor of superoxide and NO synthesis; the inhibition of the formation of reactive oxygen and nitrogen species are partly based on its ability to inhibit the serine phosphorylation of Iκ-Bα.
Interaction of iron with polyphenolic compounds: application to antioxidant characterization.
TLDR
Both flavonoids and nonflavonoids effectively inhibited the formation of thiobarbituric acid-reactive substances as a marker of lipid peroxidation of microsomes from rat liver.
Inhibitory action of eugenol compounds on the production of nitric oxide in RAW264.7 macrophages.
TLDR
Anti-inflammatory action of eugenol compounds may be explained by the inhibition of NO production and COX-2 expression, the pro-inflammatory mediators.
Aluminum-induced apoptosis in PC12D Cells
The addition of aluminum-maltol complex to PC12D cells induced a time-dependent and concentration-dependent growth inhibition as well as cell death, whereas aluminum chloride or maltol alone did not
Prooxidant activity of flavonoids: copper-dependent strand breaks and the formation of 8-hydroxy-2'-deoxyguanosine in DNA.
TLDR
Treatment of calf thymus DNA with these flavonoids or ascorbate plus copper produced 8-hydroxy-2'-deoxyguanosine and Mutagenic and carcinogenic action of flavonoid may be explained by the prooxidant effects of the compounds.
Prooxidant Action of Maltol: Role of Transition Metals in the Generation of Reactive Oxygen Species and Enhanced Formation of 8-hydroxy-2′-deoxyguanosine Formation in DNA
TLDR
It is suggested that maltol can stimulate the copper reduction coupled with the oxidation of ascorbate, resulting in the production of superoxide radical which in turn converts to hydrogen peroxide and hydroxyl radical.
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