M. Yoshimura

Publications714
h-index70
Citations17,995
Highly Influential Citations374
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Endothelial nitric oxide synthase gene is positively associated with essential hypertension.
TLDR
A missense variant, Glu298Asp, in exon 7 of the eNOS gene is identified and demonstrated that it is associated with both coronary spastic angina and myocardial infarction, which suggests thatIt is a genetic susceptibility factor for essential hypertension. Expand
Localization and Mechanism of Secretion of B‐Type Natriuretic Peptide in Comparison With Those of A‐Type Natriuretic Peptide in Normal Subjects and Patients With Heart Failure
TLDR
Examination of the sources and mechanisms of the secretion of BNP in comparison with those of ANP in control subjects and in patients with heart failure concludes that BNP is secreted mainly from the left ventricle in normal adult humans as well as in Patients with left ventricular dysfunction. Expand
Increased Plasma Levels of Brain Natriuretic Peptide in Patients With Acute Myocardial Infarction
TLDR
It is concluded that the plasma level of brain natriuretic peptide is increased markedly in patients with acute myocardial infarction and may reflect the degree of left ventricular dysfunction in these patients. Expand
Elevated levels of VE-cadherin-positive endothelial microparticles in patients with type 2 diabetes mellitus and coronary artery disease.
TLDR
The CD144-positive EMP exist in human plasma, and plasmaCD144-EMP levels can be a clinically specific and quantitative marker of EC dysfunction and/or injury and may be useful for identifying DM patients with increased risk of CAD. Expand
Different Secretion Patterns of Atrial Natriuretic Peptide and Brain Natriuretic Peptide in Patients With Congestive Heart Failure
TLDR
It is concluded that plasma levels of BNP mainly reflect the degree of ventricular overload and that the secretion patterns of ANP and BNP vary with underlying cardiac disorders of CHF with different degrees of overload in atria and ventricles. Expand
A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese
TLDR
The missense Glu298Asp variant in the eNOS gene is found by the analysis of its entire 26 coding regions and is significantly associated with coronary spasm. Expand
Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction.
TLDR
There was a significant association of the missense Glu298Asp variant of the eNOS gene with MI, which may be due to the impaired effects of NO on the cardiovascular system: dysregulation of vascular tone, platelet aggregation and leukocyte adhesion and smooth muscle cell proliferation, all of which promote coronary atherosclerosis and thrombosis. Expand
Polymorphism in the 5'-flanking region of human glutamate-cysteine ligase modifier subunit gene is associated with myocardial infarction.
TLDR
Findings suggest that the -588T polymorphism of the GCLM gene may suppress G CLM gene induction in response to oxidants and that it is a genetic risk factor for MI. Expand
T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm.
TLDR
Findings strongly suggest that the T-786-->C mutation in the eNOS gene reduces the endothelial NO synthesis and predisposes the patients with the mutation to coronary spasm. Expand
Augmented secretion of brain natriuretic peptide in acute myocardial infarction.
TLDR
Results indicate that BNP is secreted from the heart much more acutely and prominently than ANP in the early phase of AMI, in association with left ventricular dysfunction. Expand
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