Localization and Mechanism of Secretion of B‐Type Natriuretic Peptide in Comparison With Those of A‐Type Natriuretic Peptide in Normal Subjects and Patients With Heart Failure
- H. Yasue, M. Yoshimura, K. Nakao
- Medicine, BiologyCirculation
- 1 July 1994
Examination of the sources and mechanisms of the secretion of BNP in comparison with those of ANP in control subjects and in patients with heart failure concludes that BNP is secreted mainly from the left ventricle in normal adult humans as well as in Patients with left ventricular dysfunction.
Increased Plasma Levels of Brain Natriuretic Peptide in Patients With Acute Myocardial Infarction
It is concluded that the plasma level of brain natriuretic peptide is increased markedly in patients with acute myocardial infarction and may reflect the degree of left ventricular dysfunction in these patients.
Endothelial nitric oxide synthase gene is positively associated with essential hypertension.
- Y. Miyamoto, Y. Saito, K. Nakao
- Biology, MedicineHYPERTENSION
- 1 July 1998
A missense variant, Glu298Asp, in exon 7 of the eNOS gene is identified and demonstrated that it is associated with both coronary spastic angina and myocardial infarction, which suggests thatIt is a genetic susceptibility factor for essential hypertension.
Elevated levels of VE-cadherin-positive endothelial microparticles in patients with type 2 diabetes mellitus and coronary artery disease.
- Hidenobu Koga, S. Sugiyama, H. Ogawa
- Medicine, BiologyJournal of the American College of Cardiology
- 17 May 2005
T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm.
- M. Nakayama, H. Yasue, K. Nakao
- Biology, MedicineCirculation
- 8 June 1999
Findings strongly suggest that the T-786-->C mutation in the eNOS gene reduces the endothelial NO synthesis and predisposes the patients with the mutation to coronary spasm.
Different Secretion Patterns of Atrial Natriuretic Peptide and Brain Natriuretic Peptide in Patients With Congestive Heart Failure
- M. Yoshimura, H. Yasue, H. Imura
- Medicine, BiologyCirculation
- 1 February 1993
It is concluded that plasma levels of BNP mainly reflect the degree of ventricular overload and that the secretion patterns of ANP and BNP vary with underlying cardiac disorders of CHF with different degrees of overload in atria and ventricles.
Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction.
- Y. Shimasaki, H. Yasue, K. Nakao
- Medicine, BiologyJournal of the American College of Cardiology
- 1 June 1998
Gender and the renin–angiotensin–aldosterone system
- K. Komukai, S. Mochizuki, M. Yoshimura
- Biology, MedicineFundamental & Clinical Pharmacology
- 1 December 2010
The effects of sex hormones on the RAAS can explain at least some of the gender differences in cardiovascular and kidney diseases.
A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese
- M. Yoshimura, H. Yasue, K. Nakao
- Biology, MedicineHuman Genetics
- 8 September 1998
The missense Glu298Asp variant in the eNOS gene is found by the analysis of its entire 26 coding regions and is significantly associated with coronary spasm.
Polymorphism in the 5'-flanking region of human glutamate-cysteine ligase modifier subunit gene is associated with myocardial infarction.
- Shin-ichi Nakamura, K. Kugiyama, H. Ogawa
- BiologyCirculation
- 25 June 2002
Findings suggest that the -588T polymorphism of the GCLM gene may suppress G CLM gene induction in response to oxidants and that it is a genetic risk factor for MI.
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