• Publications
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In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer’s disease
PurposeAmyloid β protein (Aβ) is known as a pathological substance in Alzheimer’s disease (AD) and is assumed to coexist with a degree of activated microglia in the brain. However, it remains unclearExpand
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Neuroinflammation in the living brain of Parkinson's disease.
Evidence shows that neuronal injury accompanies neuroinflammatory reactions in the brain, and well as in Parkinson's disease (PD) animal models, in which the loss of dopamine neurons is associatedExpand
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Amygdala kindling induces upregulation of mRNA for NKCC1, a Na+, K+–2Cl− cotransporter, in the rat piriform cortex
GABA, the main inhibitory neurotransmitter in the brain, elicits a hyperpolarizing response by activation of the GABA(A)-receptor/chloride-channel complex under conditions of normal Cl(-)Expand
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Extrastriatal spreading of microglial activation in Parkinson’s disease: a positron emission tomography study
BackgroundThe neuroinflammatory glial response contributes to the degenerative process in Parkinson’s disease (PD). However, the pattern of microglial progression remains unclear.MethodsWe evaluatedExpand
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Layer-specific expression of Cl− transporters and differential [Cl−]i in newborn rat cortex
GABA is the main inhibitory neurotransmitter in the adult brain. However, GABAergic transmission is depolarizing during early postnatal development, suggesting that changes in the expression ofExpand
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Changes in chloride homeostasis-regulating gene expressions in the rat hippocampus following amygdala kindling
In a rat kindling model, we examined expression patterns of NKCC1, KCC1, KCC2, and CLC-2. In the dentate granule cell layer, there was an activity-dependent increase in NKCC1 mRNA but significantExpand
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Progression from Unilateral to Bilateral Parkinsonism in Early Parkinson Disease: Implication of Mesocortical Dopamine Dysfunction by PET
It is still unclear why some early Parkinson disease (PD) patients with unilateral parkinsonism develop bilateral parkinsonism soon after the diagnosis is made as Hoehn and Yahr (HY) stage 1 andExpand
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  • Open Access
In vivo direct relation of tau pathology with neuroinflammation in early Alzheimer’s disease
ObjectiveNeuronal damage and neuroinflammation are important events occurring in the brain of Alzheimer’s disease (AD). The purpose of this study was to clarify in vivo mutual relationships amongExpand
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Neuroinflammation following disease modifying therapy in multiple sclerosis: A pilot positron emission tomography study
INTRODUCTION Chronic activation of microglia accelerates the neurodegenerative process in multiple sclerosis (MS). Although disease modifying therapy (DMT) is reportedly effective forExpand
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Depiction of microglial activation in aging and dementia: Positron emission tomography with [11C]DPA713 versus [11C](R)PK11195
The presence of activated microglia in the brains of healthy elderly people is a matter of debate. We aimed to clarify the degree of microglial activation in aging and dementia as revealed byExpand
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