• Publications
  • Influence
The inflammatory response in stroke
Recent works in the area of stroke and brain ischemia has demonstrated the significance of the inflammatory response accompanying necrotic brain injury. Acutely, this response appears to contributeExpand
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Neuroprotective mechanisms of hypothermia in brain ischaemia
  • M. Yenari, H. Han
  • Biology, Medicine
  • Nature Reviews Neuroscience
  • 22 February 2012
Cooling can reduce primary injury and prevent secondary injury to the brain after insults in certain clinical settings and in animal models of brain insult. The mechanisms that underlie theExpand
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Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex.
We characterize the survival, migration, and differentiation of human neurospheres derived from CNS stem cells transplanted into the ischemic cortex of rats 7 days after distal middle cerebral arteryExpand
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Serial MRI after transient focal cerebral ischemia in rats: dynamics of tissue injury, blood-brain barrier damage, and edema formation.
BACKGROUND AND PURPOSE With the advent of thrombolytic therapy for acute stroke, reperfusion-associated mechanisms of tissue injury have assumed greater importance. In this experimental study, weExpand
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Optimal depth and duration of mild hypothermia in a focal model of transient cerebral ischemia: effects on neurologic outcome, infarct size, apoptosis, and inflammation.
BACKGROUND AND PURPOSE Mild hypothermia is possibly the single most effective method of cerebroprotection developed to date. However, many questions regarding mild hypothermia remain to be addressedExpand
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A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia
Following neuronal injury, microglia initiate repair by phagocytosing dead neurons without eliciting inflammation. Prior evidence indicates triggering receptor expressed by myeloid cells‐2 (TREM2)Expand
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Anti-Inflammatory Effects of the 70 kDa Heat Shock Protein in Experimental Stroke
The 70-kDa heat shock protein (Hsp70) is involved in protecting the brain from a variety of insults including stroke. Although the mechanism has been largely considered to be because of its chaperoneExpand
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Antiapoptotic and anti-inflammatory mechanisms of heat-shock protein protection.
We and others have previously shown that heat-shock proteins (HSPs) are involved in protecting the brain from a variety of insults including stroke, epilepsy, and other related insults. While theExpand
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Differential Neuroprotection from Human Heat Shock Protein 70 Overexpression in in Vitro and in Vivo Models of Ischemia and Ischemia-like Conditions
We previously showed that overexpressing the 70-kDa inducible heat shock protein in primary astrocyte cultures and in a rodent stroke model using viral vectors resulted in protection from ischemiaExpand
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Agmatine reduces infarct area in a mouse model of transient focal cerebral ischemia and protects cultured neurons from ischemia-like injury
Agmatine is a primary amine formed by the decarboxylation of L-arginine synthesized in mammalian brain. In this study, we investigated the neuroprotective effect of agmatine on ischemic andExpand
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