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A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides
Triacylglycerols are among the most attractive alternative raw materials for biofuel development. Current oil plant-based technologies are limited in terms of triacylglycerol production capacity and…
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Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
TLDR
This study clearly demonstrated that the coverage of N-glycosites could be significantly increased due to the adoption of multiple enzyme digestion, and led to the establishment of the largest data set of glycoproteome from human liver up to now.
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Pyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1
TLDR
The results provided the first phosphorylome of PKM2 and revealed a constitutive mTORC1 activating mechanism in cancer cells, which was correlated with elevated S202/203 phosphorylation, activated m TORC1 and inhibited autophagy.
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Method development of efficient protein extraction in bone tissue for proteome analysis.
TLDR
It was demonstrated that the developed extraction method of proteins in bone tissue was very efficient for comprehensive analysis of bone proteome and might be helpful for clarifying the mechanisms of bone diseases.
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An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
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A large-scale protein phosphorylation analysis reveals novel phosphorylation motifs and phosphoregulatory networks in Arabidopsis.
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CD90/THY1 is over-expressed in prostate cancer-associated fibroblasts and could serve as a cancer biomarker
TLDR
Proteomic analysis of urine from patients with prostate cancer identified CD90; conversely, CD90 was not detected in the urine of post-prostatectomy patients, and this urinary CD90 protein was a variant CD90protein not known to be expressed by such cells as lymphocytes that express CD90.
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Development of efficient protein extraction methods for shotgun proteome analysis of formalin-fixed tissues.
TLDR
Valuable proteome information could be obtained by shotgun proteome analysis of formalin-fixed tissue, which presents a new approach for disease biomarker discovery.
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Development of Glycoprotein Capture-Based Label-Free Method for the High-throughput Screening of Differential Glycoproteins in Hepatocellular Carcinoma*
TLDR
The developed method was an effective approach to quantitatively analyze glycoproteins in human serum and could be further applied in the biomarker discovery for HCC and other cancers.
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Large‐scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography
TLDR
It was found that phosphopeptides were highly enriched by SAX and majority of unmodified peptides did not bind onto SAX, and it was demonstrated that SAX have the ability to fractionate phosphopePTides under gradient elution based on their different interaction with SAX adsorbent.
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