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A novel humanized anti-human death receptor 5 antibody CS-1008 induces apoptosis in tumor cells without toxicity in hepatocytes.
TLDR
CS-1008 has a selective toxicity toward tumor cells expressing DR5 and the potential for antitumor efficacy in human malignancies and in combination with gemcitabine or docetaxel demonstrated enhanced antitumors activity against MIA PaCa-2 or NCI-H2122 cells, respectively. Expand
High expression of Bcl-xL in delayed apoptosis of canine neutrophils induced by lipopolysaccharide.
TLDR
Results indicated that Bcl-xL was proved have an important role in the inhibition of canine neutrophil apoptosis by LPS. Expand
Aberrations of the p53 tumor suppressor gene in various tumors in dogs.
TLDR
It is indicated that p53 gene can be a target for gene therapy for tumors in dogs, which may be 1 of the multiple step-wise genetic changes during tumorigenesis. Expand
Molecular analysis of multidrug resistance in feline lymphoma cells.
TLDR
The basic structure of the feline MDR1 gene was essentially the same as that of multidrug-resistance genes of other species, and Expression of P-gp appeared to be one of the mechanisms responsible for the development ofMultidrug resistance in feline lymphoma cell lines in vitro. Expand
Establishment and characterization of eight feline mammary adenocarcinoma cell lines.
TLDR
Eight new feline mammary adenocarcinoma cell lines derived from either primary or metastatic lesions were established and tumor masses were developed in nude mice by subcutaneous inoculation of the cells that were histologically identical to their original mammary tumor lesions. Expand
Telomere length and telomerase activity in canine mammary gland tumors.
TLDR
Telomeres in mammary gland tumors were slightly shorter than in normal tissue specimens, but telomere length could not be directly compared between groups, because mean age of dogs was significantly different between groups. Expand
Results of hyperamplification of centrosomes in naturally developing tumors of dogs.
TLDR
Hyperamplification of centrosomes is a novel tumor marker for use in cytologic and histologic examinations of clinical specimens obtained from dogs. Expand
Nucleotide sequence and expression of the feline vascular endothelial growth factor.
TLDR
Though predicted fVEGF polypeptide was two amino acid residues shorter than human VEGF165, a potential glycosylation site and regions critical for receptor binding were conserved in all the species examined. Expand
Measurement of telomerase activity in dog tumors.
TLDR
The results obtained in this study indicated that telomerase should be a useful diagnostic marker for a variety of dog tumors, and it may serve as a target for antitumor chemotherapy. Expand
Development of DS‐5573a: A novel afucosylated mAb directed at B7‐H3 with potent antitumor activity
TLDR
The results suggest that antitumor activity of DS‐5573a is mediated by effector cells, and this mAb could be a promising antitUMor therapy for patients with a wide range of B7‐H3‐expressing tumors. Expand
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