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A novel humanized anti-human death receptor 5 antibody CS-1008 induces apoptosis in tumor cells without toxicity in hepatocytes.
BACKGROUND The antitumor activity of CS-1008, a humanized agonistic anti-human death receptor (DR) 5 antibody, was investigated in preclinical models. MATERIALS AND METHODS Cytotoxicity of CS-1008Expand
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High expression of Bcl-xL in delayed apoptosis of canine neutrophils induced by lipopolysaccharide.
The expression of Bcl-2 family members, Bcl-xL, Bcl-2, Mcl-1 and Bax was investigated in delayed apoptosis of canine neutrophils induced by lipopolysaccharide (LPS). Apoptotic cell rates inExpand
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Aberrations of the p53 tumor suppressor gene in various tumors in dogs.
OBJECTIVE To evaluate aberrations of the p53 tumor suppressor gene in naturally developing tumors in dogs. SAMPLE POPULATION Tumor specimens from 15 dogs with various tumors, including malignantExpand
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Molecular analysis of multidrug resistance in feline lymphoma cells.
OBJECTIVE To evaluate the mechanism of multidrug resistance in feline lymphoma cell lines. SAMPLE POPULATION A feline lymphoma cell line (FT-1) and its adriamycin (ADM)-resistant sublineExpand
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Establishment and characterization of eight feline mammary adenocarcinoma cell lines.
Eight new feline mammary adenocarcinoma cell lines derived from either primary or metastatic lesions were established. The morphology of all the cell lines was epithelioid and round to spindle inExpand
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Telomere length and telomerase activity in canine mammary gland tumors.
OBJECTIVE To measure telomere length and telomerase activity in naturally occurring canine mammary gland tumors. SAMPLE POPULATION 27 mammary gland tumor specimens obtained during resection orExpand
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Results of hyperamplification of centrosomes in naturally developing tumors of dogs.
OBJECTIVE To evaluate results of centrosome hyperamplification in naturally developing tumors of dogs. SAMPLE POPULATION Tumor specimens from 9 dogs with tumors (rhabdomyosarcoma, osteosarcoma,Expand
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Antiviral activity and inhibition of topoisomerase by ofloxacin, a new quinolone derivative.
The antiviral activity of ofloxacin, a new quinolone derivative, against vaccinia virus (VV), herpes simplex virus (HSV) and influenza virus (InfV) was evaluated in both in vitro and in vivoExpand
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Nucleotide sequence and expression of the feline vascular endothelial growth factor.
Vascular endothelial growth factor (VEGF) is an angiogenic factor which targets vascular endothelial cells. In this study, cDNA encoding a feline VEGF (fVEGF) isoform was cloned from a felineExpand
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Measurement of telomerase activity in dog tumors.
Telomeres are specific structures present at the end of liner chromosomes. DNA polymerase can not synthesize the end of liner DNA and, as a result, the telomeres become progressively shortened byExpand
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