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Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis
TLDR
This is the first report linking TGFA to human OA, which may serve as a new target for future therapies and two loci known to be associated with cartilage thickness are confirmed. Expand
Heritability of Thoracic Spine Curvature and Genetic Correlations With Other Spine Traits: The Framingham Study
TLDR
Thoracic spine curvature may be heritable and share genetic factors with other age‐related spine traits including trunk muscle size, vertebral fracture, and bone mineral density. Expand
Genome-wide meta-analysis identified novel variant associated with hallux valgus in Caucasians
TLDR
This report identifies a novel genome-wide significant locus in the intronic region of CLCA2 on chromosome 1, rs55807512, an expression quantitative trait locus for COL24A1, a member of the collagen gene family, in hallux valgus. Expand
Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain
TLDR
This first reported meta-analysis of GWAS for CBP identified and replicated a genetic locus associated with CBP (SOX5), and identified 2 other loci that reached genome-wide significance in a 2-stage joint meta- analysis (CCDC26/GSDMC and DCC). Expand
Genome‐Wide Association Study of Radiographic Knee Osteoarthritis in North American Caucasians
TLDR
A genome‐wide association study of radiographically defined tibiofemoral knee OA in 3,898 cases and 3,168 controls from 4 well‐characterized North American cohorts, and replication analysis of previously reported OA loci are performed. Expand
Genetic epidemiology of osteoarthritis: recent developments and future directions
TLDR
This review focuses on the following areas: identification of new genes through genetic association studies, including genome-wide association studies; family-based studies and extreme osteoarthritis phenotypes; endophenotypes and pain; and overlap of osteoartritis with other age-related disorders. Expand
Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand
TLDR
The results indicate that the association between the MGP variant and increased risk for hand OA is caused by a lower expression of MGP, which may increase the burden of hand Oa by decreased inhibition of cartilage calcification. Expand
Genetic association analysis of radiographic hip osteoarthritis with established loci for bone mineral density: data from the osteoarthritis initiative
TLDR
It was found that each condition was also characterized by the expression of specific sets of genes, suggesting the activation of a common reparatory mechanism. Expand
Dynamic Effects of Depressive Symptoms on Osteoarthritis Knee Pain
TLDR
To estimate the dynamic causal effects of depressive symptoms on osteoarthritis (OA) knee pain, a large number of patients with a history of depression were randomly assigned to receive either a statin or an anti-depression pill. Expand
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