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Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix
TLDR
A novel approach to generate transplantable liver grafts using decellularized liver matrix that preserves the structural and functional characteristics of the native microvascular network, allowing efficient recellularization of the liver matrix with adult hepatocytes and subsequent perfusion for in vitro culture.
Mesenchymal Stem Cells: Mechanisms of Immunomodulation and Homing
TLDR
The known mechanisms of immunomodulation and homing of MSCs are described and contextualized to understand a reported side effect of M SC therapy, cancer development.
Long‐Term in Vitro Function of Adult Hepatocytes in a Collagen Sandwich Configuration
TLDR
It is suggested that simple manipulations of the configuration of extracellular elements can dramatically alter the behavior of cultured hepatocytes.
Effect of cell–cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells
TLDR
Although the precise mechanisms by which nonparenchymal cells modulate the hepatocyte phenotype remain unelucidated, some new insights on the modes of cell signaling, the extent of cell–cell interaction, and the ratio of cell populations are noted.
Tissue engineering and regenerative medicine: history, progress, and challenges.
TLDR
This review highlights the modest beginnings of tissue engineering and regenerative medicine and describes three application examples that are in various stages of development, ranging from relatively mature to ongoing proof-of-concept (cartilage) to early stage (liver).
Hepatocyte function and extracellular matrix geometry: long‐term culture in a sandwich configuration
TLDR
Adult rat hepatocytes cultured in a collagen sandwich system maintained normal morphology and a physiological rate of albumin secretion for at least 42 days and provided a simple method for their long‐term maintenance.
Mesenchymal Stem Cell-Derived Molecules Reverse Fulminant Hepatic Failure
TLDR
It is reported that the administration of MSC-derived molecules in two clinically relevant forms-intravenous bolus of conditioned medium or extracorporeal perfusion with a bioreactor containing MSCs-can provide a significant survival benefit in rats undergoing FHF and support the role of chemokines and altered leukocyte migration as a novel therapeutic modality for FHF.
Controlling cell interactions by micropatterning in co-cultures: hepatocytes and 3T3 fibroblasts.
TLDR
This co-culture technique allowed manipulation of the initial cellular microenvironment without variation of cell number and was able to control the level of homotypic interaction in cultures of a single cell type and the degree of heterotypic contact in co-cultures over a wide range.
Mesenchymal stem cell–derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo
TLDR
These data provide the first clear evidence that MSC‐CM therapy provides trophic support to the injured liver by inhibiting hepatocellular death and stimulating regeneration, potentially creating new avenues for the treatment of FHF.
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