• Publications
  • Influence
Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix
Orthotopic liver transplantation is the only available treatment for severe liver failure, but it is currently limited by organ shortage. One technical challenge that has thus far limited theExpand
  • 1,004
  • 26
  • PDF
Long‐Term in Vitro Function of Adult Hepatocytes in a Collagen Sandwich Configuration
In an effort to reconstruct the cellular polarity normally found in the liver, adult rat hepatocytes were sandwiched between two layers of hydrated rat tail tendon collagen matrix. Functionally,Expand
  • 651
  • 24
Mesenchymal Stem Cells: Mechanisms of Immunomodulation and Homing
Mesenchymal stem cell (MSC) transplantation has been explored as a new clinical approach to repair injured tissue. A growing corpus of studies have highlighted two important aspects of MSC therapy:Expand
  • 531
  • 23
Effect of cell–cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells
Heterotypic cell interaction between parenchymal cells and nonparenchymal neighbors has been reported to modulate cell growth, migration, and/or differentiation. In both the developing and adultExpand
  • 794
  • 16
  • PDF
Hepatocyte function and extracellular matrix geometry: long‐term culture in a sandwich configuration
Adult rat hepatocytes cultured in a collagen sandwich system maintained normal morphology and a physiological rate of albumin secretion for at least 42 days. Hepatocytes cultured on a single layer ofExpand
  • 680
  • 15
Culture matrix configuration and composition in the maintenance of hepatocyte polarity and function.
Several extracellular matrix (ECM) configurations involving type I collagen and Matrigel were examined for their ability to support differentiated function and polarity of cultured adult ratExpand
  • 197
  • 14
Mesenchymal Stem Cell-Derived Molecules Reverse Fulminant Hepatic Failure
Modulation of the immune system may be a viable alternative in the treatment of fulminant hepatic failure (FHF) and can potentially eliminate the need for donor hepatocytes for cellular therapies.Expand
  • 449
  • 12
  • PDF
Controlling cell interactions by micropatterning in co-cultures: hepatocytes and 3T3 fibroblasts.
The repair or replacement of damaged tissues using in vitro strategies has focused on manipulation of the cell environment by modulation of cell-extracellular matrix interactions, cell-cellExpand
  • 498
  • 12
  • PDF
Effect of extracellular matrix topology on cell structure, function, and physiological responsiveness: hepatocytes cultured in a sandwich configuration
Extracellular matrix (ECM) geometry is an important modulator of cell polarity and function. For example, 3‐dimensional matrices often more effectively induce differentiated cell function thanExpand
  • 352
  • 12
Mesenchymal stem cell–derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo
Orthotopic liver transplantation is the only proven effective treatment for fulminant hepatic failure (FHF), but its use is limited because of organ donor shortage, associated high costs, and theExpand
  • 425
  • 10
  • PDF