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FKBP12.6-Mediated Stabilization of Calcium-Release Channel (Ryanodine Receptor) as a Novel Therapeutic Strategy Against Heart Failure
Background—The development of heart failure is tightly correlated with a decrease in the stoichiometric ratio for FKBP12.6 binding to the ryanodine receptor (RyR) in the sarcoplasmic reticulum (SR).… Expand
Catecholaminergic Polymorphic Ventricular Tachycardia Is Caused by Mutation-Linked Defective Conformational Regulation of the Ryanodine Receptor
Rationale: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is caused by a single point mutation in a well-defined region of the cardiac type 2 ryanodine receptor (RyR)2. However, the… Expand
Altered intracellular Ca2+ handling in heart failure.
Structural and functional alterations in the Ca2+ regulatory proteins present in the sarcoplasmic reticulum have recently been shown to be strongly involved in the pathogenesis of heart failure.… Expand
Mechanisms of Disease: ryanodine receptor defects in heart failure and fatal arrhythmia
- M. Yano, Takeshi Yamamoto, Y. Ikeda, M. Matsuzaki
- Nature Clinical Practice Cardiovascular Medicine
Abnormal regulation of intracellular Ca2+ by sarcoplasmic reticulum plays a part in the mechanism underlying contractile and relaxation dysfunction in heart failure (HF). The… Expand
Scavenging free radicals by low-dose carvedilol prevents redox-dependent Ca2+ leak via stabilization of ryanodine receptor in heart failure.
- M. Mochizuki, M. Yano, +7 authors M. Matsuzaki
- Journal of the American College of Cardiology
- 24 April 2007
OBJECTIVES We investigated whether defective intracellular Ca2+ handling is corrected by carvedilol in heart failure. BACKGROUND In heart failure, the interaction between the N-terminal and central… Expand
Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction.
- X. Xu, M. Yano, +12 authors M. Matsuzaki
- Biology, Medicine
- Biochemical and biophysical research…
- 9 April 2010
Calmodulin (CaM), one of the accessory proteins of the cardiac ryanodine receptor (RyR2), is known to play a significant role in the channel regulation of the RyR2. However, the possible involvement… Expand
Correction of Defective Interdomain Interaction Within Ryanodine Receptor by Antioxidant Is a New Therapeutic Strategy Against Heart Failure
Background— Defective interdomain interaction within the ryanodine receptor (RyR2) seems to play a key role in the pathogenesis of heart failure, as shown in recent studies. In the present study we… Expand
Defective Regulation of Interdomain Interactions Within the Ryanodine Receptor Plays a Key Role in the Pathogenesis of Heart Failure
Background—According to our hypothesis, 2 domains within the ryanodine receptor (RyR) of sarcoplasmic reticulum (SR) (N-terminal [0 to 600] and central [2000 to 2500] domains), where many mutations… Expand
Observation of the highly organized development of granule cells in rat cerebellar organotypic cultures
- M. Tanaka, Atsuhisa Tomita, S. Yoshida, M. Yano, Hiroshi Shimizu
- Biology, Medicine
- Brain Research
- 4 April 1994
Cerebellar slices of 9-day-old rats were cultured for a week at the interface between air and a culture medium containing horse serum and hormone cocktail, and the development of granule cells was… Expand