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Hepatitis C virus‐core and non structural proteins lead to different effects on cellular antioxidant defenses
Chronic hepatitis C virus (HCV) infection leads to increased oxidative stress in the liver. Hepatic antioxidant enzymes provide an important line of defense against oxidative injury. To understandExpand
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Prevalence and risk factors for anabolic-androgenic steroid abuse among Jordanian collegiate students and athletes.
BACKGROUND The study was conducted to measure the extent of androgenic steroids abuse among two targeted groups in Jordan, college students and athletes, and the risk factors associated with thisExpand
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2DG enhances the susceptibility of breast cancer cells to doxorubicin
Abstract2DG causes cytotoxicity in cancer cells by disrupting thiol metabolism while Doxorubicin (DOX) induces cytotoxicity in tumor cells by generating reactive oxygen species (ROS). Here weExpand
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Subcellular localization of Pseudomonas pyocyanin cytotoxicity in human lung epithelial cells.
The Pseudomonas aeruginosa secretory product pyocyanin damages lung epithelium, likely due to redox cycling of pyocyanin and resultant superoxide and H(2)O(2) generation. Subcellular site(s) ofExpand
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Pathogenicity of Toxigenic Fusarium proliferatum from Date Palm in Saudi Arabia.
Fusarium proliferatum was isolated for the first time from roots and leaves of declining date-palm trees (Phoenix dactylifera L.) in the Al-Qassim and Al Medina Al Monawara regions in Saudi Arabia.Expand
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Anti‐PD‐1 synergizes with cyclophosphamide to induce potent anti‐tumor vaccine effects through novel mechanisms
Programmed death‐1 receptor (PD‐1) is expressed on T cells following TCR activation. Binding of this receptor to its cognate ligands, programmed death ligand (PDL)‐1 and PDL‐2, down‐regulates signalsExpand
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The Pseudomonas secretory product pyocyanin inhibits catalase activity in human lung epithelial cells.
Pyocyanin, produced by Pseudomonas aeruginosa, has many deleterious effects on human cells that relate to its ability to generate reactive oxygen species (ROS), such as superoxide and hydrogenExpand
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Selective Inhibition of Regulatory T Cells by Targeting the PI3K–Akt Pathway
Abu-Eid, Samara, and colleagues used PI3K–Akt pathway inhibitors to selectively disrupt homeostasis of immunosuppressive Tregs in naïve and tumor-bearing mice, and to enhance vaccine-inducedExpand
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2-deoxy-D-Glucose Synergizes with Doxorubicin or L-Buthionine Sulfoximine to Reduce Adhesion and Migration of Breast Cancer Cells.
BACKGROUND Cancer metastasis depends on cell motility which is driven by cycles of actin polymerization and depolymerization. Reactive oxygen species (ROS) and metabolic oxidative stress have longExpand
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Datura Aqueous Leaf Extract Enhances Cytotoxicity via Metabolic Oxidative Stress on Different Human Cancer Cells
This study was designed to evaluate the cytotoxic effect ﺔﺘﺒﻧ قاروﻷ ﻲﺋﺎﻤﻟا ﺺﻠﺨﺘﺴﻤﻟا ﺔﻴﻤﺳ ىﺪﻣ ﻢﻴﻘﺘﻟ ﺔﺳارﺪﻟا ﻩﺬه ﺖﻤﻤﺻ of aqueous Datura stramonium leaf extract on different human cancer cell lines inExpand
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