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Cure of mice infected with Trypanosoma rhodesiense by cis-diamminedichloroplatinum (II) and disulfiram rescue.
Mice infected with Trypanosoma rhodesiense were treatment concurrently with cis-diamminedichloroplatinum (II) (DDP), disulfiram, and hydration, and inoculation of blood or suspensions of brain or heart from these animals did not produce disease in recipient mice.
Orally-administered silver sulfadiazine: chemotherapy and toxicology in CF-1 mice; Plasmodium berghei (Malaria) and Pseudomonas aeruginosa.
- M. Wysor
- Medicine, BiologyChemotherapy
Doses of 1,050 mg/kg/day had significant activity against systemic infections of Pseudomonas aeruginosa, and Parasitemia was reduced to zero in 1-3 days and antimalarial activity was not inhibited significantly with doses of 313 mg/ kg/day of PABA, thereby indicating that silver sulfadiazine's antimalaria mode of action is different from that of the sulfonamides.
The autoradiographic uptake and turnover of [1-3H]-galactose in mouse periodontal tissues.
On the mode of action of silver sulfadiazine.
Silver sulfadiazine (CF-100) binds to deoxyribonucleic acid (DNA) but not to ribonucleic acid (RNA). DNA degradation is not observed. Nucleic acid and protein synthesis are not inhibited by silver sul
Phototoxicity of the chemotherapeutic agents hematoporphyrin D, meso-tetra(p-sulfophenyl)porphine and zinc-tetra(p-sulfophenyl)porphine.
- M. Grenan, M. Tsutsui, M. Wysor
- Chemistry, BiologyResearch communications in chemical pathology and…
- 1 November 1980
Phototoxicity was seen after intraperitoneal administration but not after oral administration, and three porphyrin compounds were significantly more phototoxic than the positive control, 6,8-dichloro-2-phenyl-alpha- 2-piperidyl-4-quinoline methanol.
Antibacterial properties of silver chelates of uracil and uracil derivatives in vitro.
Silver chelates of uracil and uracil derivatives yield biologically active compounds effective against several strains of bacteria including P. aeruginosa with minimal toxicity to t
Deoxyribonucleic acid repair replication in Pseudomonas aeruginosa after sublethal doses of silver sulfadiazine.
The bacteriostatic-bacteriocidal activity may be related to the rate of drug interaction with Pseudomonas DNA compared to the rates of ‘excision-repair’.
Antimalarials: screening of (orally administered) silver solfonamides against Plasmodium berghei.
- M. Wysor
- Chemistry, MedicineChemotherapy
Orally administered silver sulfadiazine is effective against Plasmodium berghei and attempts to synthesize an active analogue with antimalarial activity failed, which suggests that the antimalaria activity of silver sulfADiazines is stereo-specific.
Reactivity of Silver Sulfadiazine and the Silver Uracils with the Glucose Oxidase of Aspergillus niger
Bi[5,5-bis(hydroxymethyl)-3-methyl-2-oxomorpholin-3-yl] (BHM-3 dimer). A low toxicity, water-soluble, one-electron reducing agent
Bi[5,5-bis(hydroxymethyl)-3-methyl-2-oxomorpholin-3-yl] (BHM-3 dimer) was synthesized by condensing tris(hydroxymethyl)aminomethane with ethyl pyruvate to form…