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Down-regulation of the GABA-ergic system in selected brain areas of spontaneously hypertensive rats (SHR).
TLDR
The results suggest that activity of GABA-ergic system differs substantially in SHR and WKY rats brain, and differences appear already in young prehypertensive SHR rats as well as in the early stages of hypertension.
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Functional state of GABA-ergic system in spontaneously hypertensive rats.
TLDR
Lower concentration of GABA in the CNS of spontaneously hypertensive rats (SHR) may be one of factors responsible for different behavior of SHR and their altered responsiveness to psychotropic drugs.
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The activity of glutamate decarboxylase and the turnover of gamma-aminobutyric acid in spontaneously hypertensive rats.
TLDR
The obtained results indicate that in the arterial hypertension the activity of GABA-ergic system is impaired.
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Effect of clonidine on Mood pressure and GABAergic mechanisms us spontaneously hypertensive rats
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Increased activity of the GABAergic system in selected brain areas after chronic propranolol treatment in spontaneously hypertensive rats.
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Effect of clonidine on blood pressure and GABAergic mechanisms in spontaneously hypertensive rats.
TLDR
The data suggest that the hypotensive action of clonidine is related to stimulation of the GABAergic system and caused a marked enhancement of specific [3H]GABA binding in the hypothalamus.
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Pharmacological effects of Ukrain in rats and rabbits.
TLDR
It was found that MAP was reduced and breathing rate increased significantly in both animal species and maximum tolerated dose (MTD) of Ukrain was 10-fold higher in rats than in rabbits.
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Systemic toxicity and dermal irritation of Tołpa Peat Preparation.
TLDR
Results show that TPP may be considered as practically non toxic, in acute and chronic toxicity studies TPP was well tolerated in both animal species.
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Enhancement of GABAergic system activity by metoprolol in spontaneously hypertensive rats.
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Influence of some sulfhydryl compounds on the antineoplastic effectiveness of 5-fluorouracil and 6-mercaptopurine.
TLDR
Sulfhydryl compounds failed to change in most cases the therapeutic (antineoplastic) effect of 5-FU and 6-MP, however, certain doses of these sulfhydryL compounds enhanced the cytostatic effect of 6- MP in respect to Sa-180.
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