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GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation
A novel cytoplasmic compartment referred to as GW bodies was initially identified using human autoantibodies to a 182 kDa protein named GW182. GW bodies are small, generally spherical, cytoplasmicExpand
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Structural Rearrangement of Ebola Virus VP40 Begets Multiple Functions in the Virus Life Cycle
Proteins, particularly viral proteins, can be multifunctional, but the mechanisms behind multifunctionality are not fully understood. Here, we illustrate through multiple crystal structures,Expand
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  • Open Access
Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia.
Defining the mechanisms underlying the control of mitochondrial fusion and fission is critical to understanding cellular adaptation to diverse physiological conditions. Here we demonstrate thatExpand
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Coxsackievirus Infection Induces Autophagy-Like Vesicles and Megaphagosomes in Pancreatic Acinar Cells In Vivo
ABSTRACT Autophagy can play an important part in protecting host cells during virus infection, and several viruses have developed strategies by which to evade or even exploit this homeostaticExpand
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Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarction.
Ischemia resulting from myocardial infarction (MI) promotes VEGF expression, leading to vascular permeability (VP) and edema, a process that we show here contributes to tissue injury throughout theExpand
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  • Open Access
Ultrastructural and Biophysical Characterization of Hepatitis C Virus Particles Produced in Cell Culture
ABSTRACT We analyzed the biochemical and ultrastructural properties of hepatitis C virus (HCV) particles produced in cell culture. Negative-stain electron microscopy revealed that the particles wereExpand
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Short-term fasting induces profound neuronal autophagy
Disruption of autophagy—a key homeostatic process in which cytosolic components are degraded and recycled through lysosomes—can cause neurodegeneration in tissue culture and in vivo. Up-regulation ofExpand
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  • Open Access
A crucial role of mitochondrial Hsp40 in preventing dilated cardiomyopathy
Many heat-shock proteins (Hsp) are members of evolutionarily conserved families of chaperone proteins that inhibit the aggregation of unfolded polypeptides and refold denatured proteins, therebyExpand
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In Vivo Functional Assay of a Recombinant Aquaporin in Pichia pastoris
ABSTRACT The water channel protein PvTIP3;1 (α-TIP) is a member of the major intrinsic protein (MIP) membrane channel family. We overexpressed this eukaryotic aquaporin in the methylotrophic yeastExpand
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  • Open Access
S1P3 receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNF.
  • Y. Gon, M. Wood, +4 authors H. Rosen
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 28 June 2005
Pulmonary pathologies including adult respiratory distress syndrome are characterized by disruption of pulmonary integrity and edema compromising respiratory function. Sphingosine 1-phosphate (S1P)Expand
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