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Detergent effects on enzyme activity and solubilization of lipid bilayer membranes.
Over 50 detergents were tested to establish which would be most effective in releasing proteins from membrane-bounded compartments without denaturing them. Various concentrations each of detergentExpand
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Pharmacological characterization of the 5‐HT receptor‐mediated contraction in the mouse isolated ileum
The pharmacological characterization of a 5‐HT receptor‐mediated contractile response in the mouse isolated ileum is described. In the presence of methysergide (1 μM), 5‐hydroxytryptamine (5‐HT,Expand
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Lecozotan (SRA-333): A Selective Serotonin 1A Receptor Antagonist That Enhances the Stimulated Release of Glutamate and Acetylcholine in the Hippocampus and Possesses Cognitive-Enhancing Properties
Recent data has suggested that the 5-hydroxytryptamine (5-HT)1A receptor is involved in cognitive processing. A novel 5-HT1A receptor antagonist,Expand
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Function and Pharmacology of Spinally-Projecting Sympathetic Pre-Autonomic Neurones in the Paraventricular Nucleus of the Hypothalamus
The paraventricular nucleus (PVN) of the hypothalamus has been described as the "autonomic master controller". It co-ordinates critical physiological responses through control of theExpand
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Characterization of a stretch-activated potassium channel in chondrocytes
Chondrocytes possess the capacity to transduce load‐induced mechanical stimuli into electrochemical signals. The aim of this study was to functionally characterize an ion channel activated inExpand
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Activation of paraventricular nucleus neurones by the dorsomedial hypothalamus via a tachykinin pathway in rats
The dorsomedial hypothalamus (DMH) innervates the paraventricular nucleus (PVN) with substance P (SP) immunoreactive neurones. The PVN itself powerfully influences both the neuroendocrine and theExpand
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Substance P Targets Sympathetic Control Neurons in the Paraventricular Nucleus
The paraventricular nucleus (PVN) contains spinally-projecting neurons implicated in fine-tuning the cardiovascular system. In vivo activity of “presympathetic” parvocellular neurons is suppressed byExpand
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Quantitative analysis of voltage-gated potassium currents from primary equine (Equus caballus) and elephant (Loxodonta africana) articular chondrocytes.
In this comparative study, we have established in vitro models of equine and elephant articular chondrocytes, examined their basic morphology, and characterized the biophysical properties of theirExpand
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Inhibition by α‐Tetrahydrodeoxycorticosterone (THDOC) of Pre‐Sympathetic Parvocellular Neurones in the Paraventricular Nucleus of Rat Hypothalamus
α‐tetrahydrodeoxycorticosterone (THDOC) is an endogenous neuroactive steroid which increases in plasma and brain concentration during stress. It has both positive and negative modulatory effects onExpand
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Comparative studies on the activity of 3β-hydroxy-Δ5-norcholenic acid on the Δ24-sterol reductase enzyme(s) in an insect and the rat
1. 1. The effects of 3β-hydroxy-Δ5-norcholenic acids on sterol metabolism were examined in the tobacco hornworm Manduca sexta (Johannson) and the rat. 2. 2. This steroidal acid inhibited theExpand
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