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- Publications
- Influence
Goal-directed Hemostatic Resuscitation of Trauma-induced Coagulopathy: A Pragmatic Randomized Clinical Trial Comparing a Viscoelastic Assay to Conventional Coagulation Assays
- E. González, E. Moore, +14 authors A. Sauaia
- Medicine
- Annals of surgery
- 1 June 2016
Background:Massive transfusion protocols (MTPs) have become standard of care in the management of bleeding injured patients, yet strategies to guide them vary widely. We conducted a pragmatic,… Expand
Primary Fibrinolysis Is Integral in the Pathogenesis of the Acute Coagulopathy of Trauma
Background:The existence of primary fibrinolysis (PF) and a defined mechanistic link to the “Acute Coagulopathy of Trauma” is controversial. Rapid thrombelastography (r-TEG) offers point of care… Expand
Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma.
- M. Wohlauer, E. Moore, +7 authors M. Walsh
- Medicine
- Journal of the American College of Surgeons
- 1 May 2012
BACKGROUND
Our aim was to determine the prevalence of platelet dysfunction using an end point of assembly into a stable thrombus after severe injury. Although the current debate on acute traumatic… Expand
Initial experiences with point‐of‐care rapid thrombelastography for management of life‐threatening postinjury coagulopathy
BACKGROUND: Massive transfusion (MTP) protocol design is hindered by lack of accurate assessment of coagulation. Rapid thrombelastography (r‐TEG) provides point‐of‐care (POC) analysis of clot… Expand
Antiplatelet Therapy Is Associated With Decreased Transfusion-Associated Risk of Lung Dysfunction, Multiple Organ Failure, and Mortality in Trauma Patients*
Objective:To determine whether prehospital antiplatelet therapy was associated with reduced incidence of acute lung dysfunction, multiple organ failure, and mortality in blunt trauma patients.… Expand
Platelets are dominant contributors to hypercoagulability after injury
- J. Harr, E. Moore, +6 authors A. Sauaia
- Medicine
- The journal of trauma and acute care surgery
- 1 March 2013
BACKGROUND Venous thromboembolic (VTE) disease has a high incidence following trauma, but debate remains regarding optimal prophylaxis. Thrombelastography (TEG) has been suggested to be optimal in… Expand
Traumatic brain injury causes platelet adenosine diphosphate and arachidonic acid receptor inhibition independent of hemorrhagic shock in humans and rats
- F. Castellino, M. Chapman, +9 authors M. Walsh
- Medicine
- The journal of trauma and acute care surgery
- 1 May 2014
BACKGROUND Coagulopathy in traumatic brain injury (CTBI) is a well-established phenomenon, but its mechanism is poorly understood. Various studies implicate protein C activation related to the global… Expand
Proteomic Analysis of Human Mesenteric Lymph
- M. Dzieciatkowska, M. Wohlauer, +7 authors K. Hansen
- Biology, Medicine
- Shock
- 1 April 2011
Extensive animal work has established mesenteric lymph as the mechanistic link between gut ischemia/reperfusion and distant organ injury. Our trauma and transplant services provide a unique… Expand
Platelet Dysfunction is an Early Marker for Traumatic Brain Injury-Induced Coagulopathy
- P. Davis, Harsha Musunuru, +9 authors S. Thomas
- Medicine
- Neurocritical Care
- 1 April 2013
BackgroundThe goal of this study is to determine the presence of platelet dysfunction in patients with traumatic brain injury (TBI). The mechanisms underlying the coagulopathy associated with TBI… Expand
Fragmented care in the era of limited work hours: a plea for an explicit handover curriculum
- M. Wohlauer
- Medicine
- BMJ quality & safety
- 21 November 2012
The current challenge in surgical residency education, preserving a sense of accountability in an era of limited work hours and multiple transitions of care, can be accomplished through the promotion… Expand