• Publications
  • Influence
Goal-directed Hemostatic Resuscitation of Trauma-induced Coagulopathy: A Pragmatic Randomized Clinical Trial Comparing a Viscoelastic Assay to Conventional Coagulation Assays
Background:Massive transfusion protocols (MTPs) have become standard of care in the management of bleeding injured patients, yet strategies to guide them vary widely. We conducted a pragmatic,Expand
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Primary Fibrinolysis Is Integral in the Pathogenesis of the Acute Coagulopathy of Trauma
Background:The existence of primary fibrinolysis (PF) and a defined mechanistic link to the “Acute Coagulopathy of Trauma” is controversial. Rapid thrombelastography (r-TEG) offers point of careExpand
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Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma.
BACKGROUND Our aim was to determine the prevalence of platelet dysfunction using an end point of assembly into a stable thrombus after severe injury. Although the current debate on acute traumaticExpand
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Initial experiences with point‐of‐care rapid thrombelastography for management of life‐threatening postinjury coagulopathy
BACKGROUND: Massive transfusion (MTP) protocol design is hindered by lack of accurate assessment of coagulation. Rapid thrombelastography (r‐TEG) provides point‐of‐care (POC) analysis of clotExpand
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Antiplatelet Therapy Is Associated With Decreased Transfusion-Associated Risk of Lung Dysfunction, Multiple Organ Failure, and Mortality in Trauma Patients*
Objective:To determine whether prehospital antiplatelet therapy was associated with reduced incidence of acute lung dysfunction, multiple organ failure, and mortality in blunt trauma patients.Expand
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Platelets are dominant contributors to hypercoagulability after injury
BACKGROUND Venous thromboembolic (VTE) disease has a high incidence following trauma, but debate remains regarding optimal prophylaxis. Thrombelastography (TEG) has been suggested to be optimal inExpand
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Traumatic brain injury causes platelet adenosine diphosphate and arachidonic acid receptor inhibition independent of hemorrhagic shock in humans and rats
BACKGROUND Coagulopathy in traumatic brain injury (CTBI) is a well-established phenomenon, but its mechanism is poorly understood. Various studies implicate protein C activation related to the globalExpand
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Proteomic Analysis of Human Mesenteric Lymph
Extensive animal work has established mesenteric lymph as the mechanistic link between gut ischemia/reperfusion and distant organ injury. Our trauma and transplant services provide a uniqueExpand
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Platelet Dysfunction is an Early Marker for Traumatic Brain Injury-Induced Coagulopathy
BackgroundThe goal of this study is to determine the presence of platelet dysfunction in patients with traumatic brain injury (TBI). The mechanisms underlying the coagulopathy associated with TBIExpand
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Fragmented care in the era of limited work hours: a plea for an explicit handover curriculum
  • M. Wohlauer
  • Medicine
  • BMJ quality & safety
  • 21 November 2012
The current challenge in surgical residency education, preserving a sense of accountability in an era of limited work hours and multiple transitions of care, can be accomplished through the promotionExpand
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