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Clathrin-mediated entry and cellular localization of chlorotoxin in human glioma
TLDR
It is found that in human gliomas, lung carcinoma and normal vascular endothelial cells, TM601 localizes near trans-Golgi while in normal human dermal fibroblasts and astrocytes it is dispersed in the cytoplasm. Expand
Role and Mechanisms of Interleukin-1 in the Modulation of Neurotoxicity
TLDR
The results suggest that both the NMDA receptor and the IL-1 receptor are involved in microglia-mediated neurotoxicity. Expand
Extracellular Matrix Microenvironment in Glioma Progression
TLDR
The recent integrated genomic analysis identified clinically relevant subtypes of GBM with its characteristic abnormalities and revealed genomic abnormalities in GBM that relate to several signaling pathways such as Epidermal Growth Factor Receptor /Ras /PI3K known to be associated with ECM-related signaling. Expand
Cytokines and Extracellular Matrix Remodeling in the Central Nervous System * * This Chapter is dedicated to the memory of Dr. Christopher Phelps
TLDR
A number of ECM components in the CNS are described and their role in both normal physiological conditions and CNS injury is presented using examples of CNS disease involving either autoimmune (multiple sclerosis), bacterial (meningitis), viral (HIV dementia), or neoplastic (glioma) pathogenic stimuli. Expand
ACUTE STAPHYLOCOCCAL INFECTIONS IN RABBITS IRRADIATED WITH 3‐GHz MICROWAVES *
TLDR
Examining granulopoietic reaction in rabbits exposed for several weeks to microwave radiation concurrent with experimental acute staphylococcal infection suggested that the granulocyte system may react in a different manner to acute bacterial infections in animals exposed for a long time to nonthermal power densities of microwave radiation. Expand
A mouse model for the study of blood-brain barrier permeability
TLDR
A C57BL/6 mouse model may permit study of the effects of biological response modifiers (BRMs) upon the central nervous system (CNS) in healthy and diseased mice. Expand
EFFECT OF MICROWAVES ON CELL FUNCTION AND VIRUS REPLICATION IN CELL CULTURES IRRADIATED IN VITRO
TLDR
In the present study, WISH cells and virus parainfluenza 3 were chosen, because this system offers a very homogeneous cell population, distributed as a monolayer on a glass surface, and an excellent material for cytochemical and virologic change. Expand
Interleukin-2 and coculture with thymic epithelial cells synergistically induce prothymocyte differentiation and proliferation.
TLDR
It is found that a 4 day incubation of prothymocytes (derived from the spleens of nu/nu mice) with natural and recombinant interleukin-2 in the presence of human thymic epithelial cells results in their synergistic effect onProthymocyte differentiation as measured by Thy 1.2. Expand
Purified podophyllotoxin (CPH-86) inhibits lymphocyte proliferation but augments macrophage proliferation.
TLDR
The stimulation of monokine and lymphokine production by CPH-86 may represent positive features of its action and may be immunotherapeutic, and the effects on human lymphocytes and monocytes and guinea pig macrophages are examined. Expand
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