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Detection and Clinical Significance of Circulating Tumor Cells in Colorectal Cancer—20 Years of Progress
- J. Hardingham, P. Grover, M. Winter, P. Hewett, T. Price, B. Thierry
- Medicine, BiologyMolecular medicine
- 27 October 2015
Progress on CTC detection and clinical significance over the last 20 years is provided and a novel unbiased inertial microfluidics to enrich for CTC is developed, followed by identification of CTC by imaging flow cytometry.
Nanostructured polystyrene well plates allow unbiased high-throughput characterization of circulating tumor cells.
A novel unbiased CTC detection approach that combines high-throughput automated microscopy with a simple yet efficient approach for achieving a high level of tumor cell binding in standard tissue culture polystyrene (PS) well plates that has great potential toward enabling unbiased routine clinical analysis of CTCs.
Isolation of Circulating Fetal Trophoblasts Using Inertial Microfluidics for Noninvasive Prenatal Testing
It is demonstrated that trophoblastic cells isolated using inertial microfluidics could be picked and subjected to a clinically validated sequencing assay, paving the way for further validation of this technology and larger clinical studies.
Toward Intraoperative Detection of Disseminated Tumor Cells in Lymph Nodes with Silicon Nanowire Field Effect Transistors.
The SiNW FET sensing platform out-performed in both sensitivity and rapidity not only the current standard method based on pathological examination of tissue sections but also the emerging clinical gold standard based on molecular assays.
Quasi-spherical microwells on superhydrophobic substrates for long term culture of multicellular spheroids and high throughput assays.
Efficient microfluidic negative enrichment of circulating tumor cells in blood using roughened PDMS.
- L. Diéguez, M. Winter, Kyall J. Pocock, K. Bremmell, B. Thierry
- Biology, ChemistryThe Analyst
- 5 May 2015
A method for the non-biased isolation of cancer cells within a peripheral blood sample utilizing microfluidic mixing PDMS devices functionalized with anti-CD45 is reported, and up to 99.99% WBC depletion is achieved with a tumor cell recovery yield of 50%.
Simple-to-Operate Approach for Single Cell Analysis Using a Hydrophobic Surface and Nanosized Droplets.
- Meysam Rezaei, Payar Radfar, M. Winter, L. McClements, B. Thierry, M. Warkiani
- BiologyAnalytical chemistry
- 3 March 2021
A low-cost and reproducible method for rare single-cell analysis using a highly hydrophobic surface and nanosized static droplets is reported, opening a new avenue for the study of subcellular functional mechanisms, enabling the identification of rare cells of potential functional or pathogenic consequence.
Silicon nanowires field effect transistors: a comparative sensing performance between electrical impedance and potentiometric measurement paradigms.
- D. Tran, M. Winter, Chih‐Tsung Yang, R. Stockmann, A. Offenhäusser, B. Thierry
- PhysicsAnalytical chemistry
- 4 September 2019
Compared to standard potentiometric measurements, electrical impedimetric FET measurements yielded significant improvements in biosensing performances, including the limit of detection, sensing resolution and dynamic range.
A Reappraisal of Circulating Fetal Cell Noninvasive Prenatal Testing.
Beyond conventional pathology: Towards preoperative and intraoperative lymph node staging
- M. Winter, R. Gibson, A. Ruszkiewicz, S. Thompson, B. Thierry
- MedicineInternational journal of cancer
- 15 February 2015
A review critically presents the main advances in this field and discusses why these technologies have not been able to provide a better alternative to the current gold standard diagnostic technique.