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p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor.
- R. Hudziak, G. D. Lewis, M. Winget, B. Fendly, H. Shepard, A. Ullrich
- Biology, Medicine
- Molecular and cellular biology
- 1 March 1989
The HER2/c-erbB-2 gene encodes the epidermal growth factor receptorlike human homolog of the rat neu oncogene. Amplification of this gene in primary breast carcinomas has been show to correlate with… Expand
Sarcopenia is associated with postoperative infection and delayed recovery from colorectal cancer resection surgery
- J. Lieffers, O. Bathe, K. Fassbender, M. Winget, V. Baracos
- British Journal of Cancer
- 7 August 2012
Background:Skeletal muscle depletion (sarcopenia) predicts morbidity and mortality in the elderly and cancer patients.Methods:We tested whether sarcopenia predicts primary colorectal cancer resection… Expand
Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2/neu gene product.
- B. Fendly, M. Winget, R. Hudziak, M. Lipari, M. Napier, A. Ullrich
- Biology, Medicine
- Cancer research
- 1 March 1990
High levels of expression of either the epidermal growth factor receptor or the receptor-like HER2/neu gene product p185HER2 have been observed in a variety of human malignancies. Because of the… Expand
A comparison of charlson and elixhauser comorbidity measures to predict colorectal cancer survival using administrative health data
Cancer survival is related to features of the primary malignancy and concurrent presence of nonmalignant diseases (comorbidities), including weight‐related conditions (obesity, weight loss). The… Expand
Comparison of treatment received versus long-standing guidelines for stage III colon and stage II/III rectal cancer patients diagnosed in Alberta, Saskatchewan, and Manitoba in 2004.
PURPOSE Guideline-recommended treatment for stage II/III colorectal cancer includes postsurgical chemotherapy and/or radiation as standard of care. This study measures adherence to guidelines across… Expand
Epidermal growth factor and transforming growth factor alpha bind differently to the epidermal growth factor receptor.
Epidermal growth factor (EGF) and transforming growth factor alpha (TGF alpha) compete with each other for binding to the EGF receptor. These two growth factors have similar actions, but there are… Expand
Reasons physicians do not recommend and patients refuse adjuvant chemotherapy for stage III colon cancer: a population based chart review
BackgroundSurgery followed by adjuvant chemotherapy has been the standard of care for the treatment of stage III colon cancer since the early 1990’s. Despite this, large proportions of patients do… Expand
Timeliness of cancer care from diagnosis to treatment: a comparison between patients with breast, colon, rectal or lung cancer.
- Xue Li, A. Scarfe, K. King, D. Fenton, C. Butts, M. Winget
- International journal for quality in health care…
- 23 January 2013
OBJECTIVE The purpose of this study was to assess the value in measuring specific time intervals across cancer sites to identify potentially important variation in the timeliness of cancer care that… Expand
Breast cancer risk and "delayed" primary Epstein-Barr virus infection.
- Yoshimasa Yasui, J. Potter, +4 authors J. Daling
- Cancer epidemiology, biomarkers & prevention : a…
Parallel to its established causal association with both infectious mononucleosis (IM) and young adulthood Hodgkin disease (YAHD), we propose a hypothesis that "delayed" primary EBV infection (i.e.,… Expand
Development of common data elements: the experience of and recommendations from the early detection research network
- M. Winget, J. A. Baron, +5 authors Ziding Feng
- Medicine, Computer Science
- Int. J. Medical Informatics
- 1 April 2003
This communication is a report of the process and current status of the development of common data elements (CDEs) by the Early Detection Research Network (EDRN). Expand