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Lead and mercury mutagenesis: Role of H2O2, superoxide dismutase, and xanthine oxidase
TLDR
It is demonstrated that Pb2+ and Hg2+ disrupt the redox status of AS52 cells by enhancing the activities of CuZn‐SOD and XO and that there is a causal relationship between the induction of H2O2 by these metals and mutagenesis. Expand
Preservation of natural endothelial cytopathogenicity of cytomegalovirus by propagation in endothelial cells
TLDR
These studies suggest that while the fibroblast adaption process commonly employed in the propagation of CMV restricts the host range of the virus and attenuates its spectrum of cytopathic potential, endothelial-based propagation preserves the natural endothelial cy topathogenicity of the original isolate. Expand
Characterization of two monoclonal antibodies to Epstein-Barr virus diffuse early antigen which react to two different epitopes and have different biological function.
TLDR
The high frequency of recovery of hybridomas producing anti 52/50 kDa EA-D mAbs suggest that this protein may have an important role in EBV pathogenesis/replication. Expand
A mollicute (mycoplasma) DNA repair enzyme: purification and characterization of uracil-DNA glycosylase.
TLDR
The DNA repair enzyme uracil-DNA glycosylase from Mycoplasma lactucae (831-C4) was purified 1,657-fold by using affinity chromatography and chromatofocusing techniques and exhibited a biphasic response to monovalent cations and to polyamines. Expand
Antimutagenic and promutagenic activity of ascorbic acid during oxidative stress
TLDR
It is suggested that the time at which AA is administered in relation to exposure to oxidative stress has an impact on AA antimutagenic activity, and this may explain the conflicting results concerning the effectiveness of AA as a cancer chemopreventive agent. Expand
Mutagenesis of AS52 cells by low concentrations of lead(II) and mercury(II)
TLDR
It is demonstrated that low concentrations of lead ( II) and mercury (II) are mutagenic in eukaryotic cells. Expand
Lead and mercury mutagenesis: Type of mutation dependent upon metal concentration
TLDR
Results are consistent with the hypothesis that lead and mercury induce mutations in eukaryotic cells by at least two distinct mechanisms and at concentrations of equal to or less than 0.4 μM, the majority of the mutations in the gpt gene were point mutations. Expand
Ascorbic acid‐dehydroascorbate induces cell cycle arrest at G2/M DNA damage checkpoint during oxidative stress
TLDR
It is demonstrated that during periods of oxidative stress, AA functions as an antioxidant and DHA enhances transient arrest at the G2/M checkpoint by delaying the activation of cyclin B‐cdc2. Expand
Induction of a deoxyuridine triphosphate nucleotidohydrolase activity in Epstein-Barr virus-infected cells.
TLDR
The expression of the EBV-specified dUTPase is prevented by phosphonoacetic acid indicating that its expression is dependent uponEBV-DNA replication. Expand
Health literacy and performance on the Mini-Mental State Examination
TLDR
The results suggest that the lower MMSE scores for patients with low health literacy are only partly due to 'test bias' and also result from true differences in cognitive functioning. Expand
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