• Publications
  • Influence
Neuronal nicotinic receptors: a perspective on two decades of drug discovery research.
Neuronal nicotinic acetylcholine receptors (nAChRs) have been a target for drug discovery efforts, primarily for CNS indications, for the past two decades. While nicotine and related natural productsExpand
  • 206
  • 5
Recent clinical failures in Parkinson's disease with apoptosis inhibitors underline the need for a paradigm shift in drug discovery for neurodegenerative diseases.
Understanding the mechanisms of neuronal death in concert with the identification of drugable molecular targets key to this process has held great promise for the development of novel chemicalExpand
  • 93
  • 5
Commentary: genome-based CNS drug discovery: D-amino acid oxidase (DAAO) as a novel target for antipsychotic medications: progress and challenges.
  • M. Williams
  • Biology, Medicine
  • Biochemical pharmacology
  • 1 December 2009
Antipsychotics, the drugs used currently for the treatment of schizophrenia, produce their therapeutic effects via the blockade of dopamine receptors. These compounds are, however, limited in theirExpand
  • 25
  • 4
Defining and characterizing drug/compound function.
The receptor concept, now more than century old, remains the core concept in understanding the mechanisms of disease causality and drug action. Originally formulated in the early 1900s, receptorExpand
  • 49
  • 3
Progress in Alzheimer's disease drug discovery: an update.
  • M. Williams
  • Medicine
  • Current opinion in investigational drugs
  • 2009
While Alzheimer's disease (AD) represents a major healthcare challenge, with 25 to 34 million individuals currently affected worldwide and triple this number of patients projected by 2050, the drugsExpand
  • 38
  • 3
Animal models of asthma: reprise or reboot?
Animal models of disease represent the pinnacle of hierarchical research efforts to validate targets and compounds for therapeutic intervention. Yet models of asthma, particularly in the mouse,Expand
  • 58
  • 2
Developing predictive CSF biomarkers-a challenge critical to success in Alzheimer's disease and neuropsychiatric translational medicine.
The need to develop effective treatments for Alzheimer's disease has been confounded by repeated clinical failures where promising new chemical entities that have been extensively characterized inExpand
  • 39
  • 2
Alzheimer's disease (AD) therapeutics - 2: Beyond amyloid - Re-defining AD and its causality to discover effective therapeutics.
Compounds targeted for the treatment of Alzheimer's Disease (AD) have consistently failed in clinical trials despite evidence for target engagement and pharmacodynamic activity. This questions theExpand
  • 13
  • 2
A New Look at Global Forest Histories of Land Clearing
Uncertainty about historical evidence of forest clearing is highlighted; nevertheless, its longevity and basic importance for survival make an understanding of the process important. First,Expand
  • 35
  • 2
Target identification and validation in drug discovery: the role of proteomics.
Proteomics, the study of cellular protein expression, is an evolving technology platform that has the potential to identify novel proteins involved in key biological processes in the cell that mayExpand
  • 53
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