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Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels.
IMPORTANCE Rates of testosterone therapy are increasing and the effects of testosterone therapy on cardiovascular outcomes and mortality are unknown. A recent randomized clinical trial ofExpand
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Somatic and germ-line mutations of the HRPT2 gene in sporadic parathyroid carcinoma.
BACKGROUND We looked for mutations of the HRPT2 gene, which encodes the parafibromin protein, in sporadic parathyroid carcinoma because germ-line inactivating HRPT2 mutations have been found in aExpand
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Molecular biology of the pituitary gonadotropins.
Introduction THE pituitary gonadotropins, LH and FSH, play a central role in the mammalian reproductive process. Synthesized in the gonadotropes of the pituitary, the gonadotropins bind to receptorsExpand
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Androgen therapy in women: an Endocrine Society Clinical Practice guideline.
OBJECTIVE The objective was to provide guidelines for the therapeutic use of androgens in women. PARTICIPANTS The Task Force was composed of a chair, selected by the Clinical GuidelinesExpand
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Reexamination of testosterone, dihydrotestosterone, estradiol and estrone levels across the menstrual cycle and in postmenopausal women measured by liquid chromatography–tandem mass spectrometry
Measuring serum androgen levels in women has been challenging due to limitations in method accuracy, precision sensitivity and specificity at low hormone levels. The clinical significance of changesExpand
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Challenges to the measurement of estradiol: an endocrine society position statement.
OBJECTIVE The objective of the study was to evaluate the current state of clinical assays for estradiol in the context of their applications. PARTICIPANTS The participants were appointed by theExpand
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Liganded androgen receptor interaction with beta-catenin: nuclear co-localization and modulation of transcriptional activity in neuronal cells.
A yeast two-hybrid assay was employed to identify androgen receptor (AR) protein partners in gonadotropin-releasing hormone neuronal cells. By using an AR deletion construct (AR-(Delta371-485)) as aExpand
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Androgen therapy in women: a reappraisal: an Endocrine Society clinical practice guideline.
OBJECTIVE To update practice guidelines for the therapeutic use of androgens in women. PARTICIPANTS A Task Force appointed by the Endocrine Society, American Congress of Obestricians andExpand
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Growth arrest-specific gene 6 (Gas6)/adhesion related kinase (Ark) signaling promotes gonadotropin-releasing hormone neuronal survival via extracellular signal-regulated kinase (ERK) and Akt.
We identified Ark, the mouse homolog of the receptor tyrosine kinase Axl (Ufo, Tyro7), in a screen for novel factors involved in GnRH neuronal migration by using differential-display PCR on cellExpand
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Novel Mechanism for Gonadotropin-Releasing Hormone Neuronal Migration Involving Gas6/Ark Signaling to p38 Mitogen-Activated Protein Kinase
ABSTRACT Gonadotropin-releasing hormone (GnRH) is the central regulator of the reproductive axis. Normal sexual maturation depends on the migration of GnRH neurons from the olfactory placode to theExpand
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