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CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
Aberrant DNA methylation of CpG islands has been widely observed in human colorectal tumors and is associated with gene silencing when it occurs in promoter areas. A subset of colorectal tumors hasExpand
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Epigenetic stem cell signature in cancer
Embryonic stem cells rely on Polycomb group proteins to reversibly repress genes required for differentiation. We report that stem cell Polycomb group targets are up to 12-fold more likely to haveExpand
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Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer.
Polycomb group proteins (PCGs) are involved in repression of genes that are required for stem cell differentiation. Recently, it was shown that promoters of PCG target genes (PCGTs) are 12-fold moreExpand
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Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer
Breast cancer is one of the most common cancers in humans and will on average affect up to one in eight women in their lifetime in the United States and Europe. The Women’s Health Initiative and theExpand
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FBXW7/hCDC4 is a general tumor suppressor in human cancer.
The ubiquitin-proteasome system is a major regulatory pathway of protein degradation and plays an important role in cellular division. Fbxw7 (or hCdc4), a member of the F-box family of proteins,Expand
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Methylation and silencing of the retinoic acid receptor-beta2 gene in breast cancer.
BACKGROUND A growing body of evidence supports the hypotheses that the retinoic acid receptor beta2 (RAR-beta2) gene is a tumor suppressor gene and that the chemopreventive effects of retinoids areExpand
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DNA methylation and breast carcinogenesis
Knowledge about breast carcinogenesis has accumulated during the last decades but has barely been translated into strategies for early detection or prevention of this common disease. Changes in DNAExpand
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Independent surrogate variable analysis to deconvolve confounding factors in large-scale microarray profiling studies
We present a modified SVA, called Independent Surrogate Variable Analysis (ISVA), to identify features correlating with a phenotype of interest in the presence of potential confounding factors. Expand
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An Epigenetic Signature in Peripheral Blood Predicts Active Ovarian Cancer
Background Recent studies have shown that DNA methylation (DNAm) markers in peripheral blood may hold promise as diagnostic or early detection/risk markers for epithelial cancers. However, to date noExpand
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Methylation changes in faecal DNA: a marker for colorectal cancer screening?
DNA methylation is a common molecular alteration in colorectal cancer cells. We report an assessment of faecal DNA from patients with colorectal cancer and controls to determine the feasibility,Expand
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