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Synchronized oscillations in interneuron networks driven by metabotropic glutamate receptor activation
It is proposed that interneuron network oscillations, in conjunction with intrinsic membrane resonances and long-loop (such as thalamocortical) interactions, contribute to 40-Hz rhythms in vivo.
Inhibition-based rhythms: experimental and mathematical observations on network dynamics.
Analysis of gamma rhythms in the rat hippocampus in vitro and in vivo.
- R. Traub, M. Whittington, S. B. Colling, G. Buzsáki, J. Jefferys
- BiologyThe Journal of physiology
- 1 June 1996
The data suggest that gamma‐frequency EEG activity arises in the hippocampus when pools of interneurones receive a tonic or slowly varying excitation, and on the parameters regulating the inhibitory coupling between the interneeurones.
Gamma rhythms and beta rhythms have different synchronization properties.
- N. Kopell, G. Ermentrout, M. Whittington, R. Traub
- BiologyProceedings of the National Academy of Sciences…
- 15 February 2000
A simplified model is used to show that the different rhythms in the CA1 region of the hippocampus employ different dynamical mechanisms to synchronize, based on different ionic currents, which are consistent with data suggesting that gamma rhythms are used for relatively local computations whereas beta rhythms are use for higher level interactions involving more distant structures.
Impaired Electrical Signaling Disrupts Gamma Frequency Oscillations in Connexin 36-Deficient Mice
A mechanism for generation of long-range synchronous fast oscillations in the cortex
It is shown that in rat hippocampal slices interneurons do indeed fire spike doublets under conditions in which gamma oscillations are synchronized over several millimetres, whereas they fire single spikes under other conditions.
Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy
This article critically discusses the challenges and opportunities for improving cognition in individuals suffering from psychiatric disorders, highlighting the needs to characterize the cellular and cerebral circuits underpinning cognitive function and identify more effective treatments.
Prion protein is necessary for normal synaptic function
It is argued that loss of function of PrPc may contribute to the early synaptic loss3 and neuronal degeneration seen in Creutzfeldt–Jakob disease and scrapie and bovine spongiform encephalopathy in animals.
Recruitment of Parvalbumin-Positive Interneurons Determines Hippocampal Function and Associated Behavior
Single-column thalamocortical network model exhibiting gamma oscillations, sleep spindles, and epileptogenic bursts.
It is shown that epileptiform bursts, including double and multiple bursts, containing VFO occur in rat auditory cortex in vitro, in the presence of kainate, when both GABA(A) and GABA(B) receptors are blocked.