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Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?
Methods used to trap RS, including spin trapping and aromatic hydroxylation, are critically examined, with a particular emphasis on those methods applicable to human studies and methods used to detect RS in cell culture.
Characterization of a Novel, Water-Soluble Hydrogen Sulfide–Releasing Molecule (GYY4137): New Insights Into the Biology of Hydrogen Sulfide
The results identify GYY4137 as a slow-releasing H2S compound with vasodilator and antihypertensive activity that is likely to prove useful in the study of the many and varied biological effects of H1N1.
The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite ‘scavenger’?
H2S has the potential to act as an inhibitor of peroxynitrite‐mediated processes in vivo and that the potential antioxidant action of H2S deserves further study, given that extracellular GSH levels in the brain are very low.
Hydrogen sulfide is a novel mediator of lipopolysaccharide‐induced inflammation in the mouse
It is suggested that H2S exhibits proinflammatory activity in endotoxic shock and a new approach to the development of novel drugs for this condition is suggested.
Regulation of vascular nitric oxide in vitro and in vivo; a new role for endogenous hydrogen sulphide?
The aim of these experiments was to evaluate the significance of the chemical reaction between hydrogen sulphide (H2S) and nitric oxide (NO) for the control of vascular tone.
Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels.
Evidence for the formation of a novel nitrosothiol from the gaseous mediators nitric oxide and hydrogen sulphide.
Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools.
- M. Whiteman, Sophie Le Trionnaire, M. Chopra, B. Fox, J. Whatmore
- BiologyClinical science
- 1 December 2011
The suitability of proposed 'biomarkers' of H2S synthesis and metabolism are critically discussed, and the complexities of the currently used pharmacological H 2S 'donor' molecules and 'specific' H2 S synthesis inhibitors are highlighted in their application to studying the role of H1N1 in human disease.
The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages.
- M. Whiteman, Ling-Xia Li, P. Rose, Choon‐Hong Tan, D. Parkinson, P. Moore
- BiologyAntioxidants and Redox Signaling
- 15 May 2010
The effects of H(2)S on the inflammatory process are complex and dependent not only on H(1beta, IL-6, NO, PGE(2), and TNF-alpha but also on the rate of H2S generation, which may explain some of the apparent discrepancies in the literature regarding the pro- versus antiinflammatory role of the molecule.
The gastrointestinal tract: A major site of antioxidant action?
The argument is developed that the high levels of antioxidants present in certain foods (fruits, vegetables, grains) and beverages (e.g. green tea) play an important role in protecting the gastrointestinal tract itself from oxidative damage, and in delaying the development of stomach, colon and rectal cancer.