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Selective serotonin-reuptake inhibitors and risk of persistent pulmonary hypertension of the newborn.
BACKGROUND Persistent pulmonary hypertension of the newborn (PPHN) is associated with substantial infant mortality and morbidity. A previous cohort study suggested a possible association betweenExpand
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Causal knowledge as a prerequisite for confounding evaluation: an application to birth defects epidemiology.
Common strategies to decide whether a variable is a confounder that should be adjusted for in the analysis rely mostly on statistical criteria. The authors present findings from the SloneExpand
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Medication use during pregnancy, with particular focus on prescription drugs: 1976-2008.
OBJECTIVE The objective of the study was to provide information on overall medication use throughout pregnancy, with particular focus on the first trimester and specific prescription medications. Expand
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Periconceptional Folic Acid Exposure and Risk of Occurrent Neural Tube Defects
Objectives. —A recent controlled trial has established that use of a 4-mg folic acid supplement before and during early pregnancy reduces the risk of recurrent neural tube defects (NTDs) by 72%. TheExpand
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Multivitamin supplementation and risk of birth defects.
It is widely accepted that supplementation with folic acid, a B vitamin, reduces the risk of neural tube defects (NTDs). This case-control study tested the hypothesis that multivitamins reduce risksExpand
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First-trimester use of selective serotonin-reuptake inhibitors and the risk of birth defects.
BACKGROUND The risk of birth defects after antenatal exposure to selective serotonin-reuptake inhibitors (SSRIs) remains controversial. METHODS We assessed associations between first-trimesterExpand
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Folic acid antagonists during pregnancy and the risk of birth defects.
BACKGROUND Multivitamin supplementation in pregnant women may reduce the risks of cardiovascular defects, oral clefts, and urinary tract defects in their infants. We evaluated whether the folic acidExpand
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Prepregnant weight in relation to risk of neural tube defects.
OBJECTIVE To examine the relation between prepregnant weight and the risk of neural tube defects (NTDs). DESIGN Data were collected from 1988 to 1994 in a case-control surveillance program of birthExpand
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Maternal obesity, gestational diabetes, and central nervous system birth defects.
BACKGROUND Maternal obesity and diabetes are both associated with increased risk of congenital central nervous system (CNS) malformations in the offspring and may share a common underlying mechanism.Expand
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Neural tube defects in relation to use of folic acid antagonists during pregnancy.
Periconceptional folic acid supplementation reduces the risk of neural tube defects (NTDs). To determine whether periconceptional exposure to folic acid antagonists (FAAs) might therefore increaseExpand
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