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The ARP2/3 complex: an actin nucleator comes of age
The cellular functions of the actin cytoskeleton require precise regulation of both the initiation of actin polymerization and the organization of the resulting filaments. The actin-related… Expand
A nucleator arms race: cellular control of actin assembly
For over a decade, the actin-related protein 2/3 (ARP2/3) complex, a handful of nucleation-promoting factors and formins were the only molecules known to directly nucleate actin filament formation de… Expand
Actin polymerization is induced by Arp 2/3 protein complex at the surface of Listeria monocytogenes
The pathogenic bacterium Listeria monocytogenes is capable of directed movement within the cytoplasm of infected host cells. Propulsion is thought to be driven by actin polymerization at the… Expand
Cellular control of actin nucleation.
Eukaryotic cells use actin polymerization to change shape, move, and internalize extracellular materials by phagocytosis and endocytosis, and to form contractile structures. In addition, several… Expand
The Human Arp2/3 Complex Is Composed of Evolutionarily Conserved Subunits and Is Localized to Cellular Regions of Dynamic Actin Filament Assembly
- M. Welch, Angela H. DePace, S. Verma, A. Iwamatsu, T. Mitchison
- Biology, Medicine
- The Journal of cell biology
- 28 July 1997
The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells. The human complex consists of seven subunits which include the actin related proteins Arp2 and Arp3,… Expand
WHAMM Is an Arp2/3 Complex Activator That Binds Microtubules and Functions in ER to Golgi Transport
The Arp2/3 complex is an actin nucleator that plays a critical role in many cellular processes. Its activities are regulated by nucleation-promoting factors (NPFs) that function primarily during… Expand
Actin-based motility drives baculovirus transit to the nucleus and cell surface
This virus takes a less-travelled cytoskeletal road both to reach its replication site in the nucleus and to get back to the plasma membrane to escape the host cell.
Mycobacterium marinum Escapes from Phagosomes and Is Propelled by Actin-based Motility
- Luisa M Stamm, J. Morisaki, +7 authors E. Brown
- Medicine, Biology
- The Journal of experimental medicine
- 1 November 2003
Mycobacteria are responsible for a number of human and animal diseases and are classical intracellular pathogens, living inside macrophages rather than as free-living organisms during infection.… Expand
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton
- E. A. Miao, M. Brittnacher, A. Haraga, Robert L. Jeng, M. Welch, S. Miller
- Biology, Medicine
- Molecular microbiology
- 1 April 2003
A family of nine Salmonella typhimurium type III secretion effectors with a conserved amino‐terminus have been defined. Three family members (SifA, SifB and SseJ) have previously been demonstrated to… Expand
Critical conformational changes in the Arp2/3 complex are induced by nucleotide and nucleation promoting factor.
Actin nucleation and branching by the Arp2/3 complex is tightly regulated by activating factors. However, the mechanism of Arp2/3 complex activation remains unclear. We used fluorescence resonance… Expand