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Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
TLDR
The results for 1990 and 2010 supersede all previously published Global Burden of Disease results and highlight the importance of understanding local burden of disease and setting goals and targets for the post-2015 agenda taking such patterns into account. Expand
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
TLDR
Prevalence and severity of health loss were weakly correlated and age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010, but population growth and ageing have increased YLD numbers and crude rates over the past two decades. Expand
Mediation of hippocampal mossy fiber long-term potentiation by cyclic AMP.
TLDR
It is proposed that calcium entry into the presynaptic terminal may activate Ca(2+)-calmodulin-sensitive adenylyl cyclase I which, through protein kinase A, causes a persistent enhancement of evoked glutamate release. Expand
The state of US health, 1990-2010: burden of diseases, injuries, and risk factors.
TLDR
To measure the burden of diseases, injuries, and leading risk factors in the United States from 1990 to 2010 and to compare these measurements with those of the 34 countries in the Organisation for Economic Co-operation and Development (OECD), systematic analysis of descriptive epidemiology was used. Expand
Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010
TLDR
This study represents the most extensive empirical effort as yet to measure disability weights and reports strong evidence of highly consistent results. Expand
Cognitive Outcome Following Traumatic Brain Injury
TLDR
In adults, penetrating, moderate, and severe TBIs are associated with cognitive deficits 6 months or longer postinjury. Expand
The role of Ca2+ channels in hippocampal mossy fiber synaptic transmission and long-term potentiation
TLDR
The results suggest that the induction of mossy fiber LTP is critically dependent on the entry of Ca2+ into the presynaptic terminal to trigger a series of steps resulting in the long lasting enhancement of evoked glutamate release. Expand
Perinatal Air Pollutant Exposures and Autism Spectrum Disorder in the Children of Nurses’ Health Study II Participants
TLDR
Perinatal exposure to air pollutants may increase risk for autism spectrum disorder (ASD), and future studies should consider sex-specific biological pathways connecting perinatal Exposure to pollutants with ASD. Expand
The opioid peptide dynorphin mediates heterosynaptic depression of hippocampal mossy fibre synapses and modulates long-term potentiation
TLDR
These findings demonstrate a physiological role for a neuropeptide in the central nervous system, provide a functional basis for the coexistence of a neuroPEptide with classic neurotransmitters and demonstrate the very different roles played by these two classes of signalling molecules. Expand
Attention-Deficit/Hyperactivity Disorder and Urinary Metabolites of Organophosphate Pesticides
TLDR
Findings support the hypothesis that organophosphate exposure, at levels common among US children, may contribute to ADHD prevalence and Prospective studies are needed to establish whether this association is causal. Expand
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