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Updating cost-effectiveness--the curious resilience of the $50,000-per-QALY threshold.
The ratio of $50,000 per quality-adjusted life-year (QALY) gained by using a given health care intervention has long served as a benchmark for the value of U.S. health care. But evidence suggestsExpand
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Recommendations of the Panel on Cost-effectiveness in Health and Medicine.
OBJECTIVE To develop consensus-based recommendations for the conduct of cost-effectiveness analysis (CEA). This article, the second in a 3-part series, describes the basis for recommendationsExpand
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Foundations of cost-effectiveness analysis for health and medical practices.
Limits on health-care resources mandate that resource-allocation decisions be guided by considerations of cost in relation to expected benefits. In cost-effectiveness analysis, the ratio of netExpand
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QALYs: the basics.
The aim of this article is to review the concept of the qualityadjusted life-year (QALY), a widely used measure of health improvement that is used to guide health-care resource allocation decisions.Expand
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Utility Functions for Life Years and Health Status
Multiattribute utility theory is used to suggest a form for a utility function over life years and health status. The analysis is motivated by consideration of two diseases—coronary artery diseaseExpand
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Principles of good practice for decision analytic modeling in health-care evaluation: report of the ISPOR Task Force on Good Research Practices--Modeling Studies.
OBJECTIVES Mathematical modeling is used widely in economic evaluations of pharmaceuticals and other health-care technologies. Users of models in government and the private sector need to be able toExpand
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Recommendations for Reporting Cost-effectiveness Analyses
Objective. —This article, the third in a 3-part series, describes recommendations for the reporting of cost-effective analyses (CEAs) intended to improve the quality and accessibility of CEA reports.Expand
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Five-hundred life-saving interventions and their cost-effectiveness.
We gathered information on the cost-effectiveness of life-saving interventions in the United States from publicly available economic analyses. "Life-saving interventions" were defined as anyExpand
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Projected clinical benefits and cost-effectiveness of a human papillomavirus 16/18 vaccine.
BACKGROUND Human papillomavirus (HPV) vaccine may be commercially available in a few years. We explored the clinical benefits and cost-effectiveness of introducing an HPV16/18 vaccine in a populationExpand
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