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Cerebrospinal fluid and plasma biomarkers in Alzheimer disease
Intense multidisciplinary research has provided detailed knowledge of the molecular pathogenesis of Alzheimer disease (AD). This knowledge has been translated into new therapeutic strategies with… Expand
Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer's disease.
- Juan Zhou, M. Greicius, +7 authors W. Seeley
- Psychology, Medicine
- Brain : a journal of neurology
- 1 May 2010
Resting-state or intrinsic connectivity network functional magnetic resonance imaging provides a new tool for mapping large-scale neural network function and dysfunction. Recently, we showed that… Expand
Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial.
CONTEXT Docosahexaenoic acid (DHA) is the most abundant long-chain polyunsaturated fatty acid in the brain. Epidemiological studies suggest that consumption of DHA is associated with a reduced… Expand
A Network Diffusion Model of Disease Progression in Dementia
Patterns of dementia are known to fall into dissociated but dispersed brain networks, suggesting that the disease is transmitted along neuronal pathways rather than by proximity. This view is… Expand
Nearly automatic segmentation of hippocampal subfields in in vivo focal T2-weighted MRI
- P. Yushkevich, Hongzhi Wang, +5 authors S. Mueller
- Psychology, Computer Science
- 1 December 2010
We present and evaluate a new method for automatically labeling the subfields of the hippocampal formation in focal 0.5×2.0mm resolution T2-weighted magnetic resonance images that can be acquired in the routine clinical setting with under 5 min scan time. Expand
Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort
A genome-wide, whole brain approach to investigate genetic effects on neuroimaging phenotypes for identifying quantitative trait loci is described. Expand
Frontal paralimbic network atrophy in very mild behavioral variant frontotemporal dementia.
- W. Seeley, R. Crawford, +4 authors M. Gorno-Tempini
- Psychology, Medicine
- Archives of neurology
- 1 February 2008
BACKGROUND Behavioral variant frontotemporal dementia (bvFTD) strikes hardest at the frontal lobes, but the sites of earliest injury remain unclear. OBJECTIVE To determine atrophy patterns in… Expand
Hippocampal Atrophy as a Quantitative Trait in a Genome-Wide Association Study Identifying Novel Susceptibility Genes for Alzheimer's Disease
Background With the exception of APOE ε4 allele, the common genetic risk factors for sporadic Alzheimer's Disease (AD) are unknown. Methods and Findings We completed a genome-wide association study… Expand
Tensor-based morphometry as a neuroimaging biomarker for Alzheimer's disease: An MRI study of 676 AD, MCI, and normal subjects
In one of the largest brain MRI studies to date, we used tensor-based morphometry (TBM) to create 3D maps of structural atrophy in 676 subjects with Alzheimer's disease (AD), mild cognitive impairment (MCI), and healthy elderly controls, scanned as part of the Alzheimer's Disease Neuroimaging Initiative. Expand
Longitudinal stability of MRI for mapping brain change using tensor-based morphometry
We examined the robustness of different MRI scan types for mapping brain changes using tensor-based morphometry. Expand