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Transcription analysis of the genes tcdA-E of the pathogenicity locus of Clostridium difficile.
TLDR
A model for the growth-phase-related, coordinate regulation of toxin expression wherein tcdC has a negative and tCDD a positive regulatory function on transcription of the tcdD,B,E and tcdA genes is discussed. Expand
Quantitative real-time PCR detection of Zika virus and evaluation with field-caught Mosquitoes
TLDR
This assay is a useful tool for detection of ZIKV infection in regions where a number of other clinically indistinguishable arboviruses like dengue or chikungunya co-circulate. Expand
Induction of MxA Gene Expression by Influenza A Virus Requires Type I or Type III Interferon Signaling
TLDR
MxA is a unique marker for the detection of type I and type III IFN activity during virus infections and IFN therapy, and cannot be triggered directly by virus infection. Expand
Characterization of a sandfly fever Sicilian virus isolated during a sandfly fever epidemic in Turkey.
TLDR
A new phlebovirus related to sandfly fever Sicilian virus, SFTV was isolated and characterized from acute patient material, and activity seems to be changing in Turkey. Expand
One-step RT-PCR for detection of Zika virus.
TLDR
An RT-PCR assay targeting the envelope protein coding region is designed and evaluated for its specificity, detection limit, repeatability, and capacity to detect ZIKV isolates collected over a 40-year period from various African countries and hosts. Expand
Identification of Tilapia Lake Virus in Egypt in Nile tilapia affected by 'summer mortality' syndrome
TLDR
Tissue samples from seven farms affected by ‘summer mortality’ were tested at the University of Stirling for TiLV and three samples tested positive using PCR; the first time that TiLV has been identified in Egypt. Expand
Interaction of severe acute respiratory syndrome-associated coronavirus with dendritic cells.
TLDR
SARS-CoV has the ability to circumvent both the innate and the adaptive immune systems, as well as to induce a delayed activation of IFN-alpha expression. Expand
Evidence for the existence of two new members of the family Chlamydiaceae and proposal of Chlamydia avium sp. nov. and Chlamydia gallinacea sp. nov.
TLDR
Comparative genome analysis involving the type strains of currently accepted Chlamydiaceae species and the designated type strains representing the two new clades confirmed that the latter could be classified into two different species as their average nucleotide identity (ANI) values were always below 94%, both with the closest relative species and between themselves. Expand
Toxins A and B from Clostridium difficile differ with respect to enzymatic potencies, cellular substrate specificities, and surface binding to cultured cells.
TLDR
The differing enzymatic activities of Clostridium difficile toxins turned out to be the main determinant of the difference in cytotoxic potency, whereas the different in binding contributes to a lesser degree. Expand
A Novel Cytotoxin from Clostridium difficileSerogroup F Is a Functional Hybrid between Two Other Large Clostridial Cytotoxins*
TLDR
The novel hybrid toxin will broaden the utility of the LCTs for clarifying the functions of several small GTPases, now including also R-Ras, as well as considerably more potent cytotoxins than TcsL-1522. Expand
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