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Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage
The developmental origin of oligodendrocyte progenitors (OLPs) in the forebrain has been controversial. We now show, by Cre-lox fate mapping in transgenic mice, that the first OLPs originate in theExpand
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The transcription factor Sox10 is a key regulator of peripheral glial development.
The molecular mechanisms that determine glial cell fate in the vertebrate nervous system have not been elucidated. Peripheral glial cells differentiate from pluripotent neural crest cells. We showExpand
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Sox10, a Novel Transcriptional Modulator in Glial Cells
Sox proteins are characterized by possession of a DNA-binding domain with similarity to the high-mobility group domain of the sex determining factor SRY. Here, we report on Sox10, a novel proteinExpand
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The Sox9 transcription factor determines glial fate choice in the developing spinal cord.
The mechanism that causes neural stem cells in the central nervous system to switch from neurogenesis to gliogenesis is poorly understood. Here we analyzed spinal cord development of mice in whichExpand
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Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10.
Sox10 is a high-mobility-group transcriptional regulator in early neural crest. Without Sox10, no glia develop throughout the peripheral nervous system. Here we show that Sox10 is restricted in theExpand
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Interaction among SOX10, PAX3 and MITF, three genes altered in Waardenburg syndrome.
Waardenburg syndrome (WS) is an autosomal dominant disorder with an incidence of 1 in 40 000 that manifests with sensorineural deafness and pigmentation defects. It is classified into four typesExpand
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Molecular mechanism for distinct neurological phenotypes conveyed by allelic truncating mutations
The molecular mechanisms by which different mutations in the same gene can result in distinct disease phenotypes remain largely unknown. Truncating mutations of SOX10 cause either a complexExpand
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SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function.
The myelin-forming oligodendrocytes are an excellent model to study transcriptional regulation of specification events, lineage progression, and terminal differentiation in the central nervousExpand
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Functional analysis of Sox8 and Sox9 during sex determination in the mouse
Sex determination in mammals directs an initially bipotential gonad to differentiate into either a testis or an ovary. This decision is triggered by the expression of the sex-determining gene Sry,Expand
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Gene Targeting Reveals a Widespread Role for the High-Mobility-Group Transcription Factor Sox11 in Tissue Remodeling
ABSTRACT The high-mobility-group domain-containing transcription factor Sox11 is expressed transiently during embryonic development in many tissues that undergo inductive remodeling. Here we haveExpand
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