Author pages are created from data sourced from our academic publisher partnerships and public sources.
Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2.
- M. O'Connell, K. Marchbank, +24 authors A. Weeraratna
- Medicine, Biology
- Cancer discovery
- 8 October 2013
UNLABELLED An emerging concept in melanoma biology is that of dynamic, adaptive phenotype switching, where cells switch from a highly proliferative, poorly invasive phenotype to a highly invasive,… Expand
Wnt5A promotes an adaptive, senescent‐like stress response, while continuing to drive invasion in melanoma cells
- M. Webster, M. Xu, +20 authors A. Weeraratna
- Biology, Medicine
- Pigment cell & melanoma research
- 1 March 2015
We have previously shown that Wnt5A drives invasion in melanoma. We have also shown that Wnt5A promotes resistance to therapy designed to target the BRAFV600E mutation in melanoma. Here, we show that… Expand
Role of IL-6 in an IL-10 and IL-4 double knockout mouse model uniquely susceptible to acetaminophen-induced liver injury.
- M. Bourdi, D. Eiras, +4 authors L. Pohl
- Medicine, Chemistry
- Chemical research in toxicology
- 6 January 2007
Drug-induced hepatitis remains a challenging problem for drug development and safety because of the lack of animal models. In the current work, we discovered a unique interaction that makes mice… Expand
Novel Protein Kinase C-Mediated Control of Orai1 Function in Invasive Melanoma
- R. Hooper, Xuexin Zhang, +7 authors J. Soboloff
- Biology, Medicine
- Molecular and Cellular Biology
- 8 June 2015
ABSTRACT The incidence of malignant melanoma, a cancer of the melanocyte cell lineage, has nearly doubled in the past 20 years. Wnt5A, a key driver of melanoma invasiveness, induces Ca2+ signals. To… Expand
HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors.
The stress-inducible chaperone protein HSP70 (HSPA1) is implicated in melanoma development, and HSP70 inhibitors exert tumor-specific cytotoxic activity in cancer. In this study, we documented that a… Expand
In the Wnt-er of life: Wnt signalling in melanoma and ageing
Although the clinical landscape of melanoma is improving rapidly, metastatic melanoma remains a deadly disease. Age remains one of the greatest risk factors for melanoma, and patients older than 55… Expand
Metabolism of N,N′,N″-Triethylenethiophosphoramide by CYP2B1 and CYP2B6 Results in the Inactivation of Both Isoforms by Two Distinct Mechanisms
- Erin Harleton, M. Webster, Namandjé N Bumpus, U. Kent, J. Rae, P. Hollenberg
- Chemistry, Medicine
- Journal of Pharmacology and Experimental…
- 1 September 2004
The anticancer drug N,N,″N″-triethylenethiophosphoramide (tTEPA) inactivated CYP2B6 and CYP2B1 in the reconstituted system in a time-, concentration-, and NADPH-dependent manner indicative of… Expand
sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance
Cancer is a disease of ageing. Clinically, aged cancer patients tend to have a poorer prognosis than young. This may be due to accumulated cellular damage, decreases in adaptive immunity, and chronic… Expand
A Wnt-er Migration: The Confusing Role of β-Catenin in Melanoma Metastasis
The repertoire of Wnt receptors and co-receptors in melanoma cells may determine whether β-catenin promotes metastasis. Wnt signaling in melanoma is complex, requiring the coordinate expression of… Expand
Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility.
Physical changes in skin are among the most visible signs of aging. We found that young dermal fibroblasts secrete high levels of extracellular matrix (ECM) constituents, including proteoglycans,… Expand