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Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing.
Lung cancer is the leading cause of cancer-related death, with non-small cell lung cancer (NSCLC) being the predominant form of the disease. Most lung cancer is caused by the accumulation of genomic… Expand
Efficient in vitro and in vivo expression of covalently modified plasmid DNA.
- Paul S Slattum, Aaron G. Loomis, +5 authors J. Hagstrom
- Medicine, Biology
- Molecular therapy : the journal of the American…
- 1 August 2003
The tracking of plasmid DNA (pDNA) movement within cells requires the attachment of labels to the DNA in a manner such that: (a) the pDNA remains intact during the labeling process and (b) the labels… Expand
MicroRNA Labeling Methods Directly Influence the Accuracy of Expression Profiling Detection
MicroRNA (miRNA) expression profiling is a powerful and commonly used methodology for assessing the relative levels of individual miRNAs in specific tissues. To achieve accurate results using miRNA… Expand
Homology requirements for recombination in Escherichia coli ( length dependence / insulin gene / synthetic oligonucleotides / supF miniplasmid
The DNA sequence homology required for recombination in Escherichia coli has been determined by measuring the recombination frequency between insulin DNA in a miniplasmid YrVX and a homologous… Expand
- Open Access
Intracellular Localization and Expression of Labeled Plasmid DNA using Label IT Tracker TM Nucleic Acid Labeling Kits
The transfection of plasmid DNA into mammalian cells has become a routine procedure in cellular and molecular biology experiments, yet the mechanism by which the plasmid DNA reaches its nuclear… Expand
- Open Access
Improved Cellular Analysis for the Early Detection of Compound-Induced Hepatic Cytotoxicity to Reduce Animal Testing
Most conventional cell-based in vitro assays for the assessment of cell viability and cytotoxicity are disruptive endpoint assays requiring cell lysis. A non-invasive and label-free way to… Expand
Direct RNA Labeling for Microarray Profiling using the Label IT
® technology is designed to covalently attach marker molecules to nucleic acids in a simple one-step chemical reaction, allowing sensitive and precise detection of labeled samples. Label IT ®… Expand