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Nonmechanical protein can have significant mechanical stability.
Many proteins function as complex mechanochemical machinery in living cells to constantly sense, generate, and bear mechanical forces. In addition to their biological importance, these mechanicalExpand
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Poly-l-lysine Functionalization of Single-Walled Carbon Nanotubes
Single-walled carbon nanotubes (SWNTs) were covalently functionalized with biocompatible poly-l-lysine, which is useful in promoting cell adhesion. SWNTs played an important role as connectors toExpand
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Highly active horseradish peroxidase immobilized in 1-butyl-3-methylimidazolium tetrafluoroborate room-temperature ionic liquid based sol-gel host materials.
Dramatically enhanced activity and excellent thermal stability of horseradish peroxidase were obtained by immobilizing it in a 1-butyl-3-methylimidazolium tetrafluoroborate room-temperature ionicExpand
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The unfolding and folding dynamics of TNfnALL probed by single molecule force-ramp spectroscopy
Abstract Tenascin, an important extracellular matrix protein, is subject to stretching force under physiological conditions and plays important roles in regulating the cell–matrix interactions. UsingExpand
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Preparation of porous aminopropylsilsesquioxane by a nonhydrolytic sol-gel method in ionic liquid solvent.
The synthesis of porous aminopropylsilsesquioxane (APSS) has been achieved with 1-butyl-3-methylimidazolium hexafluorophosphate (BMIM(+)PF(6-)) ionic liquid (IL) as a template solvent by aExpand
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Configurational entropy modulates the mechanical stability of protein GB1.
Configurational entropy plays important roles in defining the thermodynamic stability as well as the folding/unfolding kinetics of proteins. Here we combine single-molecule atomic force microscopyExpand
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Screening the active compounds of Phellodendri Amurensis cortex for treating prostate cancer by high-throughput chinmedomics
Screening the active compounds of herbal medicines is of importance to modern drug discovery. In this work, an integrative strategy was established to discover the effective compounds and theirExpand
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Mechanical design of the third FnIII domain of tenascin-C.
By combining single-molecule atomic force microscopy (AFM), proline mutagenesis and steered molecular dynamics (SMD) simulations, we investigated the mechanical unfolding dynamics and mechanicalExpand
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Kinetic partitioning mechanism governs the folding of the third FnIII domain of tenascin-C: evidence at the single-molecule level.
Statistical mechanics and molecular dynamics simulations proposed that the folding of proteins can follow multiple parallel pathways on a rugged energy landscape from unfolded state en route to theirExpand
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Configurational entropy modulates the mechanical stability of protein GB1.
Abstract Configurational entropy plays important roles in defining the thermodynamic stability as well as the folding/unfolding kinetics of proteins. Here we combine single-molecule atomic forceExpand
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