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Monitoring and predicting land use change in Beijing using remote sensing and GIS
Rapid land use change has taken place in many mega cities of China such as Beijing over the past two decades. In this paper, land use change dynamics were investigated by the combined use ofExpand
Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis.
The results suggest that the highly ordered alterations of 5 hmC in the mouse genome are potentially crucial for the differentiation of spermatogenic cells. Expand
Association of matrix metalloproteinase (MMP)-1, 3, 9, interleukin (IL)-2, 8 and cyclooxygenase (COX)-2 gene polymorphisms with chronic periodontitis in a Chinese population.
Serum levels of all the cytokines were higher in the CP patients compared to healthy subjects, and genetic polymorphisms are associated with susceptibility to CP in Chinese population. Expand
A Novel Nicotinic Acetylcholine Receptor Subtype in Basal Forebrain Cholinergic Neurons with High Sensitivity to Amyloid Peptides
The presence of novel, functional, heteromeric α7β2-nAChRs on basal forebrain cholinergic neurons and their high sensitivity to blockade by low concentrations of oligomeric Aβ1–42 suggests possible mechanisms for deficits in cholinerential signaling that could occur early in the etiopathogenesis of AD and might be targeted by disease therapies. Expand
C2c1-sgRNA Complex Structure Reveals RNA-Guided DNA Cleavage Mechanism.
The findings indicate that sgRNA assembly is achieved through a mechanism distinct from that reported previously for Cas9 or Cpf1 endonucleases, which renders C2c1 a valuable addition to the current arsenal of genome-editing tools. Expand
Assessing structural variation in a personal genome—towards a human reference diploid genome
Describing the SV content of a personal genome with Parliament, a publicly available consensus SV-calling infrastructure that merges multiple data types and SV detection methods, reveals the limits and advantages of multiple sequencing technologies, specifically the impact of long-read SV discovery. Expand
GPS-constrained inversion of present-day slip rates along major faults of the Sichuan-Yunnan region, China
A linked-fault-element model is employed to invert for contemporary slip rates along major active faults in the Sichuan-Yunnan region (96°–108°E, 21°–35°N) using the least squares method. The modelExpand
Mapping QTLs for seed yield and drought susceptibility index in soybean (Glycine max L.) across different environments.
The identification of consistent QTLs for YP and DSI across different environments will significantly improve the efficiency of selecting for drought tolerance in soybean. Expand
Group I metabotropic glutamate receptor‐dependent TRPC channel trafficking in hippocampal neurons
The results suggest that TRPC channels are involved in generating DHPG‐induced prolonged epileptiform discharges, which is associated with a neuronal activity‐ and PLCβ1‐dependent translocation of TRPC4 and TRPC5 proteins from the plasmalemma to the cytoplasmic compartment. Expand
LSECtin expressed on melanoma cells promotes tumor progression by inhibiting antitumor T-cell responses.
The finding that common expression of LSECtin in melanoma cells engenders a mechanism of immune escape, with implications for novel immunotherapeutic combination strategies is reported. Expand