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Assessing renal function from creatinine measurements in adults with chronic renal failure.
- M. Walser
- MedicineAmerican journal of kidney diseases : the…
- 1 July 1998
Measurement of glomerular filtration rate (GFR) following the injection of one of several suitable marker substances remains the best method to determine the severity of renal insufficiency as well…
The effect of keto-analogues of essential amino acids in severe chronic uremia.
- M. Walser, A. Coulter, S. Dighe, F. R. Crantz
- MedicineThe Journal of clinical investigation
- 1 March 1973
In four patients studied at high blood urea levels, ketoacid treatment was relatively ineffective; two of these patients responded more favorably when studied again after peritoneal dialysis; one of these improved enough clinically to be managed as an out-patient for short intervals, despite virtual anuria.
A proposed mechanism for reduced creatinine excretion in severe chronic renal failure.
From calculations, decreased creatinine appearance (and excretion) of uremic patients may be explained by a constant extrarenal clearance, indicating degradation.
Prediction of glomerular filtration rate from serum creatinine concentration in advanced chronic renal failure.
In 85 patients with established chronic renal failure, urinary clearance of 99mTc-DTPA (GFR) and [Cr] were determined one to four times and averaged and the following equations were derived for predicting GFR from [Cr]-1 (mM-1), age (years) and weight (kg).
Urea metabolism in man.
In the studies reported herein, labeled urea was administered intravenously to normal subjects and the rate of extrarenal disposal was determined, indicating that 15 to 30 per cent of the urea being synthesized in normal subjects is continually being destroyed.
Creatinine excretion as a measure of protein nutrition in adults of varying age.
- M. Walser
- MedicineJPEN. Journal of parenteral and enteral nutrition
- 1 September 1987
Using published values for urinary creatinine excretion per kilogram body weight in adult subjects of varying age and values for "ideal" weight as a function of height, normal values for expected creatinines excretion are derived, allowing the derivation of an age-corrected CHI.
The renal clearance of alkali-stable inulin.
Ion association. VI. Interactions between calcium, magnesium, inorganic phosphate, citrate and protein in normal human plasma.
- M. Walser
- BiologyThe Journal of clinical investigation
- 1 April 1961
The total measured concentration of an ionizable constituent of body fluids often fails to reveal either the varied chemical forms in which it may be present, or the portion which is present as the…
The effect of a keto acid-amino acid supplement to a restricted diet on the progression of chronic renal failure.
- W. Mitch, M. Walser, T. Steinman, S. Hill, S. Zeger, K. Tungsanga
- MedicineThe New England journal of medicine
- 6 September 1984
This regimen with a low-phosphorus diet containing 20 to 30 g of mixed-quality protein, supplemented by amino acids and their keto analogues must have slowed or halted the progression of renal insufficiency in a majority of cases, especially when treatment was initiated before creatinine had reached the level of 8 mg per deciliter.
Creatinine metabolism in chronic renal failure.
Creatinine metabolism was studied in nine patients with severe chronic renal failure who were nevertheless in a nearly steady state with respect to their creatinine pool, and two pathways of metabolism were identified: a recycling ofcreatinine to creatine and an irreversible degradation of creat inine to products other than creatine.