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The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis.
- G. Steinbach, P. Lynch, +21 authors G. Kelloff
- The New England journal of medicine
- 29 June 2000
BACKGROUND Patients with familial adenomatous polyposis have a nearly 100 percent risk of colorectal cancer. In this disease, the chemopreventive effects of nonsteroidal antiinflammatory drugs may be… Expand
Early expression of cyclo‐oxygenase‐2 during sporadic colorectal carcinogenesis
Regular administration of non‐steroidal anti‐inflammatory drugs (NSAIDs) may reduce the incidence of colorectal cancer by targeting cyclo‐oxygenase‐2 (Cox‐2), a key enzyme in arachidonic acid… Expand
Upper gastrointestinal disease in patients with familial adenomatous polyposis
Upper gastrointestinal disease has become an important aspect in the management of patients with familial adenomatous polyposis (FAP).
A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor, on duodenal polyposis in familial adenomatous polyposis
Background: Non-selective cyclooxygenase (COX) inhibitors (non-steroidal anti-inflammatory drugs) inhibit large bowel carcinogenesis in patients with familial adenomatous polyposis (FAP). Their role… Expand
Can histopathologic assessment of circumferential margin after preoperative pelvic chemoradiotherapy for T3-T4 rectal cancer predict for 3-year disease-free survival?
- S. Mawdsley, R. Glynne-Jones, +14 authors M. Wallace
- International journal of radiation oncology…
- 1 November 2005
PURPOSE This study set out to determine the impact of a positive circumferential resection margin (CRM) (R1-R2) and pathologic downstaging on local recurrence and survival in patients with borderline… Expand
Can pathological complete response in the primary tumour following pre-operative pelvic chemoradiotherapy for T3–T4 rectal cancer predict for sterilisation of pelvic lymph nodes, a low risk of local…
- R. Hughes, R. Glynne-Jones, +14 authors J. Novell
- International Journal of Colorectal Disease
IntroductionLocal excision is considered inappropriate treatment for T3–T4 rectal adenocarcinomas, as it cannot provide prognostic information regarding lymph node involvement and has a high risk of… Expand
Metachronous Carcinoma of the Large Intestine and Intestinal Polyps
Multiple intestinal cancer, once a surgical curiosity, has now become so common as to merit more detailed study. It does not require a large series of cases of malignant disease of the large… Expand
Benign lymphomas of the rectum and anal canal: a study of 100 cases.
Is Colonoscopy Still Mandatory After a CT Diagnosis of Left-Sided Diverticulitis: Can Colorectal Cancer be Confidently Excluded?
BACKGROUND: It is routine practice to perform colonoscopy as a follow-up after an attack of diverticulitis, with the main aim to exclude any underlying malignancy. PURPOSE: This study aimed to… Expand
The reliability of lymph-node staging in rectal cancer after preoperative chemoradiotherapy.
- M. Beresford, R. Glynne-Jones, +19 authors R. A. Harrison
- Clinical oncology (Royal College of Radiologists…
- 1 September 2005
AIMS To determine the prognostic significance of the nodal stage and number of nodes recovered in the surgical specimen after preoperative synchronous chemoradiation (SCRT) and surgery for locally… Expand