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A receptor subtype involved in neuropeptide-Y-induced food intake
TLDR
The expression cloning of a novel Y-type receptor from rat hypothalamus is reported, which is thought to be the postulated 'feeding' receptor and may provide a new method for the study and treatment of obesity and eating disorders. Expand
Galanin receptor subtypes.
TLDR
The neuropeptide galanin, which is widely expressed in brain and peripheral tissues, exerts a broad range of physiological effects and major challenges in this field include linking the receptor clones with each of the known physiological actions and evaluating the evidence for additional galanIn receptor subtypes. Expand
Cloned Human and Rat Galanin GALR3 Receptors
TLDR
The cloning of a third galanin receptor distinct from GALR1 andGALR2 is reported, and this data confirm the functional efficacy of GALr3 receptors and further suggest that G ALR3 signaling pathways resemble those of GalR1 in that both can activate potassium channels linked to the regulation of neurotransmitter release. Expand
Cloning and Functional Expression of a Human Y4 Subtype Receptor for Pancreatic Polypeptide, Neuropeptide Y, and Peptide YY (*)
TLDR
Y4 mRNA was detected by reverse transcriptase-polymerase chain reaction in human brain, coronary artery, and ileum, suggesting potential roles for Y4 receptors in central nervous system, cardiovascular, and gastrointestinal function. Expand
Expression Cloning of a Rat Hypothalamic Galanin Receptor Coupled to Phosphoinositide Turnover*
TLDR
Activation of GALR2 receptors with porcine Galanin and other galanin analogues increased inositol phospholipid turnover and intracellular calcium levels in stably transfected Chinese hamster ovary cells and generated calcium-activated chloride currents in Xenopus oocytes, suggesting that the rat GALr2 receptor is primarily coupled to the activation of phospholIPase C. Expand
Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299.
TLDR
Results indicate that Gal(3)-selective antagonists produce anxiolytic- and antidepressant-like effects, possibly by attenuating the inhibitory influence of galanin on 5-HT transmission at the level of the dorsal raphe nucleus. Expand
Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y5 receptor.
TLDR
The data demonstrate that the NPY Y5 receptor subtype plays a role in NPY-induced food intake, but also suggest that, with chronic blockade, counterregulatory mechanisms are induced to restore appetite. Expand
Expression Cloning and Pharmacological Characterization of a Human Hippocampal Neuropeptide Y/Peptide YY Y2 Receptor Subtype (*)
TLDR
The isolation of a human Y2 (hhY2) receptor cDNA by expression cloning from a human hippocampal cDNA library is reported, using a 125I-PYY binding assay. Expand
Neuropeptide Y modulates neurotransmitter release and Ca2+ currents in rat sensory neurons
TLDR
NPY effectively inhibited the depolarization-induced release of substance P from DRG cells in vitro and may be an important regulator of sensory neuron function in vivo, according to fura-2-based microspectrofluorimetry. Expand
Distribution of the neuropeptide Y Y2 receptor mRNA in rat central nervous system.
TLDR
The present results indicate that the mRNA encoding the Y2 receptor is discretely localized in the rat brain and that the distribution is generally consistent with previous radioligand-binding studies. Expand
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