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Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials.
TLDR
Overall, RPL554 was well tolerated, and adverse events were generally mild and of equal frequency between placebo and active treatment groups. Expand
Allergic rhinitis and its pharmacology.
TLDR
This review summarizes the current knowledge of allergic rhinitis, its prevalence, pathophysiology and experimental and clinical treatments and special emphasis is placed upon potential new treatments. Expand
Markers of exacerbation severity in chronic obstructive pulmonary disease
TLDR
Arterial carbon dioxide and breathing rate varied in a consistent manner with exacerbation severity and patient setting, and many other measures showed weak correlations that should be further explored in future longitudinal studies or assessed using suggested mathematical modelling techniques. Expand
Markers of disease severity in chronic obstructive pulmonary disease.
TLDR
Little separation between disease stages is observed for many measures used in COPD diagnosis and clinical trials, demonstrating the poor sensitivity of such endpoints to define a patient's clinical status and to quantify treatment effect. Expand
Markers of exacerbation severity in chronic obstructive pulmonary disease.
TLDR
Arterial carbon dioxide tension and breathing rate varied in a consistent manner with exacerbation severity and patient setting, and many other measures showed weak correlations that should be further explored in future longitudinal studies or assessed using suggested mathematical modelling techniques. Expand
A comprehensive model of allergic rhinitis in guinea pigs.
TLDR
The model reported in this study can be used to reflect the effectiveness of drugs currently used to treat allergic Rhinitis and to investigate new potential drugs for the treatment of allergic rhinitis. Expand
Physicochemical determinants for drug induced blockade of HERG potassium channels: effect of charge and charge shielding.
TLDR
The introduction of a hydroxy group at position 3 relative to a tertiary ammonium charged center, or the introduction of hydroxy, alkoxy or amino groups at position 2 relative to the nitrogen center of an aromatic system, should provide easy access of a water molecule to the proton, thereby facilitating deprotonation and thus leading to a moderate or weak HERG/I(Kr) blockade and a reduced risk of TdP. Expand
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