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Biotransformation Patterns of 2,4,6-Trinitrotoluene by Aerobic Bacteria
Abstract. 2,4,6-Trinitrotoluene (TNT), a toxic nitroaromatic explosive, accumulates in the environment, making necessary the remediation of contaminated areas and unused materials. AlthoughExpand
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Mineralization of Acephate, a Recalcitrant Organophosphate Insecticide Is Initiated by a Pseudomonad in Environmental Samples
An aerobic bacterium capable of breaking down the pesticide acephate (O,S-dimethyl acetyl phosphoramidothioic acid) was isolated from activated sludge collected from a pesticide manufacturingExpand
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Organophosphorus hydrolase as an in vivo catalytic nerve agent bioscavenger.
The use of proteins as a treatment for organophosphorus intoxication has been investigated since A. R. Main demonstrated protective efficacy against parathion with an exogenously administeredExpand
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Balancing the stability and the catalytic specificities of OP hydrolases with enhanced V-agent activities.
Rational site-directed mutagenesis and biophysical analyses have been used to explore the thermodynamic stability and catalytic capabilities of organophosphorus hydrolase (OPH) and its geneticallyExpand
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Enzyme-based additives for paints and coatings
Active enzymes and other active biomolecules sequestered in paints and coatings have the potential to provide one of the more unique surface coatings yet identified. We report here the design andExpand
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The inhibition of antigen‐induced eosinophilia and bronchoconstriction by CDP840, a novel stereo‐selective inhibitor of phosphodiesterase type 4
1 The novel tri‐aryl ethane CDP840, is a potent and selective inhibitor of cyclic AMP phosphodiesterase type 4 (PDE 4) extracted from tissues or recombinant PDE 4 isoforms expressed in yeast (IC50s:Expand
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Molecular evolution and genetic engineering of protein domains involving aspartate transcarbamoylase.
AN INTRODUCTORY STATEMENT ...... . ... 194 PHYSIOLOGICAL ORGANIZATION OF PYRIMIDINE-ARGININE BIOSyNTHESIS 194 THE ENZYMATIC AND GENETIC ORGANIZATIONS INVOLVING ATCase....... 195 Appropriation ofExpand
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CDP840. A prototype of a novel class of orally active anti-inflammatory phosphodiesterase 4 inhibitors.
The discovery, synthesis and biological activity of a series of triarylethane phosphodiesterase 4 inhibitors is described. Structure-activity relationship studies are presented for CDP840 (29), aExpand
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A novel layer-by-layer assembled multi-enzyme/CNT biosensor for discriminative detection between organophosphorus and non-organophosphrus pesticides.
Organophosphate compounds are heavily used in agriculture and military activities, while non-organophosphate pesticides are mostly used in agriculture and home defense. Discriminative detection ofExpand
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Fluorescence-based sensing of p-nitrophenol and p-nitrophenyl substituent organophosphates.
A novel detection method for organophosphate neurotoxins has been described, based on the fluorescence quenching of a Coumarin derivative. These dyes are similar in structure to some organophosphatesExpand
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