• Publications
  • Influence
Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor.
Although changes in nucleotide sequence affecting the composition and the structure of proteins are well known, functional changes resulting from nucleotide substitutions cannot always be inferredExpand
  • 842
  • 38
  • Open Access
Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents--second edition.
Author Affiliations Patrick M. Kochanek, MD, FCCM, Professor and Vice Chair, Department of Critical Care Medicine, University of Pittsburgh School of Medicine Nancy Carney, PhD, Associate Professor,Expand
  • 511
  • 32
  • Open Access
A Rapid Murine Coma and Behavior Scale for Quantitative Assessment of Murine Cerebral Malaria
Background Cerebral malaria (CM) is a neurological syndrome that includes coma and seizures following malaria parasite infection. The pathophysiology is not fully understood and cannot be accountedExpand
  • 87
  • 10
Defining pediatric sepsis by different criteria: Discrepancies in populations and implications for clinical practice
Objective: Pediatric patients with sepsis are identified using related but distinct criteria for clinical, research, and administrative purposes. The overlap between these criteria will affect theExpand
  • 77
  • 6
On the determination of copper surface area by reaction with nitrous oxide
Abstract The chromatographic technique for determining the specific copper surface area of catalysts by reaction with nitrous oxide has been investigated. Promotion of bulk oxidation of copper inExpand
  • 342
  • 6
Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic
BackgroundTraumatic brain injury (TBI) with its associated morbidity is a major area of unmet medical need that lacks effective therapies. TBI initiates a neuroinflammatory cascade characterized byExpand
  • 160
  • 5
  • Open Access
Human herpesvirus 6 limbic encephalitis after stem cell transplantation
Central nervous system complications are common in stem cell transplant recipients, but selective involvement of the medial temporal area is unusual. The 5 patients reported here presented after stemExpand
  • 187
  • 4
Glial Activation Links Early‐Life Seizures and Long‐Term Neurologic Dysfunction: Evidence Using a Small Molecule Inhibitor of Proinflammatory Cytokine Upregulation
Summary:  Purpose: Early‐life seizures increase vulnerability to subsequent neurologic insult. We tested the hypothesis that early‐life seizures increase susceptibility to later neurologic injury byExpand
  • 99
  • 4
An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury.
Death associated protein kinase (DAPK) is a calcium and calmodulin regulated enzyme that functions early in eukaryotic programmed cell death, or apoptosis. To validate DAPK as a potential drugExpand
  • 72
  • 4
  • Open Access
Nonconvulsive Seizures Are Common in Children Treated With Extracorporeal Cardiac Life Support*
Objectives: The prevalence of electrographic seizures or nonconvulsive status epilepticus and the effect of such seizures in children treated with extracorporeal cardiac life support are not known.Expand
  • 44
  • 4