• Publications
  • Influence
Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue
Toxoplasma gondii, an obligate intracellular parasite of the phylum Apicomplexa, can cause severe disease in humans with an immature or suppressed immune system. The outcome of Toxoplasma infectionExpand
  • 496
  • 47
  • PDF
Coordinated Progression through Two Subtranscriptomes Underlies the Tachyzoite Cycle of Toxoplasma gondii
Background Apicomplexan parasites replicate by varied and unusual processes where the typically eukaryotic expansion of cellular components and chromosome cycle are coordinated with the biosynthesisExpand
  • 195
  • 35
  • PDF
A Systematic Screen to Discover and Analyze Apicoplast Proteins Identifies a Conserved and Essential Protein Import Factor
Parasites of the phylum Apicomplexa cause diseases that impact global health and economy. These unicellular eukaryotes possess a relict plastid, the apicoplast, which is an essential organelle and aExpand
  • 164
  • 26
  • PDF
Bleaching in reef corals: Physiological and stable isotopic responses.
During the late summer to fall of 1987, Caribbean reef corals experienced an intense and widespread discoloration event described as bleaching. Contrary to initial predictions, most bleached coralsExpand
  • 239
  • 24
A Novel Bipartite Centrosome Coordinates the Apicomplexan Cell Cycle
Apicomplexan parasites can change fundamental features of cell division during their life cycles, suspending cytokinesis when needed and changing proliferative scale in different hosts and tissues.Expand
  • 65
  • 20
  • PDF
The transcriptome of Toxoplasma gondii
BackgroundToxoplasma gondii gives rise to toxoplasmosis, among the most prevalent parasitic diseases of animals and man. Transformation of the tachzyoite stage into the latent bradyzoite-cyst formExpand
  • 149
  • 13
Recovery of the coral Montastrea annularis in the Florida Keys after the 1987 Caribbean “bleaching event”
Many reef-building corals and other cnidarians lost photosynthetic pigments and symbiotic algae (zooxanthellae) during the coral bleaching event in the Caribbean in 1987. The Florida Reef TractExpand
  • 149
  • 13
Changes in the Expression of Human Cell Division Autoantigen-1 Influence Toxoplasma gondii Growth and Development
Toxoplasma is a significant opportunistic pathogen in AIDS, and bradyzoite differentiation is the critical step in the pathogenesis of chronic infection. Bradyzoite development has an apparentExpand
  • 85
  • 12
  • PDF
A change in the premitotic period of the cell cycle is associated with bradyzoite differentiation in Toxoplasma gondii.
We have demonstrated that bradyzoites return to the tissue-cyst stage by a developmental pathway that is indistinguishable from that initiated by sporozoites. Mature bradyzoites, like sporozoitesExpand
  • 97
  • 11
Defining the cell cycle for the tachyzoite stage of Toxoplasma gondii.
Tachyzoite endodyogeny is characterized by a three phase cell cycle comprised of major G1 and S phases with mitosis following immediately upon the conclusion of DNA replication. Cytokinesis, whichExpand
  • 158
  • 10