• Publications
  • Influence
Calcium, ATP, and ROS: a mitochondrial love-hate triangle.
A "two-hit" hypothesis is developed, in which Ca(2+) plus another pathological stimulus can bring about mitochondrial dysfunction, and the delicate balance between the positive and negative effects of Ca( 2+) and the signaling events that perturb this balance is highlighted. Expand
Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition.
LAT1-mediated [(14)C]phenylalanine uptake was strongly inhibited in a competitive manner by aromatic-amino acid derivatives including L-dopa, alpha-methyldopa, melphalan, triiodothyronine, and thyroxine, whereas phenylalanin methyl ester, N-methyl phenylAlanine, dopamine, tyramine, carbidopa, and droxidopa did not inhibit LAT1- mediated uptake. Expand
Targeting antioxidants to mitochondria: a new therapeutic direction.
This review shall briefly discuss cellular reactive oxygen species metabolism and its role in pathophysiology; the currently existing antioxidants and possible reasons why they are not effective in ameliorating oxidative stress-mediated diseases; and recent developments in mitochondrially targeted antioxidants and their future promise for disease treatment. Expand
Molecular Identification of a Novel Carnitine Transporter Specific to Human Testis
The identification of CT2 represents an interesting evolutionary link between OCT/OCTNs and OATs, as well as provides an important insight into the maturation of human spermatozoa. Expand
Identification of an important cysteine residue in human glutamate-cysteine ligase catalytic subunit by site-directed mutagenesis.
Results indicate that cysteine-553 in h GLCLC is involved in heterodimer formation between hGLCLC and hGLR, and was more easily dissociated from hGLCRR than the wild-type hGL CLC. Expand
Metabolism of drugs by the kidney.
  • M. W. Anders
  • Chemistry, Medicine
  • Kidney international
  • 1 November 1980
A complete perspective on the role of the kidney in pharmacologic and toxicologic processes is dependent on a thorough understanding of the drug and chemical metabolic capabilities of this organ. Expand
Biotransformation of N-ethyl-N-(2-hydroxyethyl)perfluorooctanesulfonamide by rat liver microsomes, cytosol, and slices and by expressed rat and human cytochromes P450.
Results show that the major pathway for the biotransformation of N-EtFOSE is N-dealkylation to give FOSA, which explains the observation that PFOS is found in animals given N-eTFOSE. Expand
Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity.
agents that inhibit gamma-glutamyl transpeptidase, cysteine conjugate beta-lyase, and renal organic anion transport systems, namely L-(alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, and probenecid protected against S-conjugate-induced nephrotoxicity. Expand
Cytotoxicity of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine in isolated rat kidney cells.
Altered alterations in mitochondrial function were partially prevented by inhibition of DCVG and DCVC metabolism and were strongly correlated with decreases in cell viability, indicating that mitochondria may be the primary targets of nephrotoxic cysteine S-conjugates. Expand