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Calcium, ATP, and ROS: a mitochondrial love-hate triangle.
- P. Brookes, Y. Yoon, J. Robotham, M. W. Anders, S. Sheu
- BiologyAmerican journal of physiology. Cell physiology
- 1 October 2004
A "two-hit" hypothesis is developed, in which Ca(2+) plus another pathological stimulus can bring about mitochondrial dysfunction, and the delicate balance between the positive and negative effects of Ca( 2+) and the signaling events that perturb this balance is highlighted.
Targeting antioxidants to mitochondria: a new therapeutic direction.
Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition.
LAT1-mediated [(14)C]phenylalanine uptake was strongly inhibited in a competitive manner by aromatic-amino acid derivatives including L-dopa, alpha-methyldopa, melphalan, triiodothyronine, and thyroxine, whereas phenylalanin methyl ester, N-methyl phenylAlanine, dopamine, tyramine, carbidopa, and droxidopa did not inhibit LAT1- mediated uptake.
Molecular Identification of a Novel Carnitine Transporter Specific to Human Testis
The identification of CT2 represents an interesting evolutionary link between OCT/OCTNs and OATs, as well as provides an important insight into the maturation of human spermatozoa.
Biotransformation of N-ethyl-N-(2-hydroxyethyl)perfluorooctanesulfonamide by rat liver microsomes, cytosol, and slices and by expressed rat and human cytochromes P450.
- Lin Xu, D. M. Krenitsky, A. Seacat, J. Butenhoff, M. W. Anders
- Chemistry, BiologyChemical research in toxicology
- 1 May 2004
Results show that the major pathway for the biotransformation of N-EtFOSE is N-dealkylation to give FOSA, which explains the observation that PFOS is found in animals given N-eTFOSE.
Identification of an important cysteine residue in human glutamate-cysteine ligase catalytic subunit by site-directed mutagenesis.
Results indicate that cysteine-553 in h GLCLC is involved in heterodimer formation between hGLCLC and hGLR, and was more easily dissociated from hGLCRR than the wild-type hGL CLC.
Cytotoxicity of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine in isolated rat kidney cells.
Metabolism of drugs by the kidney.
- M. W. Anders
- Chemistry, BiologyKidney international
- 1 November 1980
A complete perspective on the role of the kidney in pharmacologic and toxicologic processes is dependent on a thorough understanding of the drug and chemical metabolic capabilities of this organ.
Glutathione transferase zeta-catalyzed biotransformation of dichloroacetic acid and other alpha-haloacids.
Results are consistent with a reaction mechanism that involves displacement of chloride from DCA by glutathione to afford S-(alpha-chlorocarboxymethyl)glutathione, which may undergo hydrolysis to give the hemithioacetal S-( alpha-hydroxycarboxymethy)glUTathione.