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Mechanisms of ammonia-induced cell death in rat cortical neurons: Roles of NMDA receptors and glutathione
The occurrence, nature and prevention of ammonia-induced cell death were assayed in cultured primary cortical neurons from newborn rats. Treatment with 1-10 mM ammonium chloride for 24 or 48 h,Expand
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Differential effects of vanadium, tungsten and molybdenum on inhibition of glucose formation in renal tubules and hepatocytes of control and diabetic rabbits: Beneficial action of melatonin and
Effect of vanadyl acetylacetonate (VAc), tungstate and molybdate on gluconeogenesis has been studied in isolated hepatocytes and kidney-cortex tubules. In renal tubules of control andExpand
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Diabetes-induced changes in glucose synthesis, intracellular glutathione status and hydroxyl free radical generation in rabbit kidney-cortex tubules
Diabetes-induced changes in glucose formation, intracellular and mitochondrial glutathione redox states as well as hydroxyl free radicals (HFR) generation have been investigated in rabbitExpand
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Upregulation of cerebral cortical glutathione synthesis by ammonia in vivo and in cultured glial cells: The role of cystine uptake
Glutathione (GSH) is a major antioxidant in the brain and ammonia neurotoxicity is associated with oxidative stress. In this study, we show that intracerebral administration of ammonium chlorideExpand
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Cyclic GMP in blood and minimal hepatic encephalopathy: fine-tuning of the diagnosis
Hepatic encephalopathy (HE) is a complex neuropsychiatric syndrome elicited by ammonia and other neurotoxic compounds released to blood from acutely damaged or cirrhotic liver [1]. Overt HE isExpand
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Relationship between gluconeogenesis and glutathione redox state in rabbit kidney-cortex tubules.
The intracellular glutathione redox state and the rate of glucose formation were studied in rabbit kidney-cortex tubules. In the presence of substrates effectively utilized for glucose formation, ie,Expand
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Endogenous Neuroprotectants in Ammonia Toxicity in the Central Nervous System: Facts and Hypotheses
The paper overviews experimental evidence suggestive of the engagement of three endogenous metabolites: taurine, kynurenic acid, and glutathione (GSH) in the protection of central nervous systemExpand
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Effect of Glutamine Synthesis Inhibition with Methionine Sulfoximine on the Nitric Oxide–Cyclic GMP Pathway in the Rat Striatum Treated Acutely with Ammonia: A Microdialysis Study
Ammonia neurotoxicity is associated with overactivation of N-methyl-d-aspartate (NMDA) receptors leading to enhanced nitric oxide and cyclic GMP synthesis and to accumulation of reactive oxygen andExpand
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Endogenous neuro-protectants in ammonia toxicity in the central nervous system: facts and hypotheses.
The paper overviews experimental evidence suggestive of the engagement of three endogenous metabolites: taurine, kynurenic acid, and glutathione (GSH) in the protection of central nervous systemExpand
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