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Observing Huntington’s Disease: the European Huntington’s Disease Network’s REGISTRY
TLDR
The unparalleled collection of clinical data and biomaterials within the EHDN’s REGISTRY can expedite the search for disease modifiers of age at onset and disease progression that could be harnessed for the development of novel treatments. Expand
A randomized, double-blind, placebo-controlled study of latrepirdine in patients with mild to moderate Huntington disease.
TLDR
In patients with mild to moderate Huntington disease and cognitive impairment, treatment with latrepirdine for 6 months was safe and well tolerated but did not improve cognition or global function relative to placebo. Expand
Hemifacial spasm non-motor and motor-related symptoms and their response to botulinum toxin therapy
TLDR
It was showed that muscle contractions in HFS patients are commonly accompanied by non-motor and other motor-related symptoms and most of them are reduced following BTX-A treatment. Expand
[Successful treatment with bacteriophage in purulent cerebrospinal meningitis in a newborn].
TLDR
Oral administration of specific phage preparate for the period of 5 weeks resulted in complete sterilization of cerebrospinal fluid and unquestionable improvement of child's health. Expand
Factors affecting the quality of life in hemifacial spasm patients.
TLDR
The HFS-36 score depends mostly on severity of HFS, depressive symptoms and occurrence of accompanying trismus, and improves after BTX-A treatment, particularly high in patients with multiple (> 4) H FS-related symptoms. Expand
NMDA receptor gene variations as modifiers in Huntington disease: a replication study
TLDR
These findings further implicate the N-methyl D-aspartate receptor subtype genes as loci containing variation associated with AO in HD. Expand
Tremor in hemifacial spasm patients
TLDR
The occurrence of hand tremor was associated with higher severity of HFS, as assessed by CGI score, and two patients were diagnosed with essential tremor and five control subjects revealed enhanced the physiological tremor type. Expand
Physiological reactivity of patients with endogenous and neurotic depression.
Eye movement abnormalities in essential tremor
Eye movement abnormalities are common sign of many neurodegenerative disease like Parkinson`s disease (PD), spino-cerebellar ataxia (SCA) or Huntington disease (HD). Even though essential tremor (ET)Expand
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