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2013 ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European
TLDR
A Randomized Controlled Trial of Aliskiren in the Prevention of Major Cardiovascular Events in Elderly People and the Effect of Potentially Modifiable Risk Factors associated with Myocardial Infarction is presented.
Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the
Guidelines and Expert Consensus documents aim to present management and recommendations based on all of the relevant evidence on a particular subject in order to help physicians to select the best
High Glucose Causes Upregulation of Cyclooxygenase-2 and Alters Prostanoid Profile in Human Endothelial Cells: Role of Protein Kinase C and Reactive Oxygen Species
TLDR
High glucose, via PKC signaling, induces oxidative stress and upregulation of COX-2, resulting in reduced NO availability and altered prostanoid profile.
[The progression from hypertension to congestive heart failure].
TLDR
The present paper overviews the main pathophysiological aspects of the progression from arterial hypertension to congestive heart failure and the potential therapeutic interventions able to reduce or prevent this progression.
Effects of Proprotein Convertase Subtilisin/Kexin Type 9 Antibodies in Adults With Hypercholesterolemia: A Systematic Review and Meta-analysis.
TLDR
PCSK9 antibodies seem to be safe and effective for adults with dyslipidemia in adults with hypercholesterolemia, and clinical outcome data are rare.
Natriuretic peptides in cardiovascular diseases: current use and perspectives.
TLDR
A current appraisal of NPs' clinical implications and a critical perspective of the potential therapeutic impact of pharmacological manipulation of this class of CV hormones are provided.
Gene Silencing of the Mitochondrial Adaptor p66Shc Suppresses Vascular Hyperglycemic Memory in Diabetes
Rationale: Hyperglycemic memory may explain why intensive glucose control has failed to improve cardiovascular outcomes in patients with diabetes. Indeed, hyperglycemia promotes vascular dysfunction
The natriuretic peptides system in the pathophysiology of heart failure: from molecular basis to treatment
This article overviews the natriuretic peptides (NPs) system, its role and the development of NP-based treatment of heart failure (HF).
Expert consensus document from the European Society of Cardiology on catheter-based renal denervation.
TLDR
This expert consensus document summarizes the view of an expert panel of the European Society of Cardiology and the European Association of Percutaneous Cardiovascular Interventions to provide guidance regarding guidance regarding treatment options for patients with resistant hypertension.
Rheb is a Critical Regulator of Autophagy During Myocardial Ischemia: Pathophysiological Implications in Obesity and Metabolic Syndrome
TLDR
Inactivation of Rheb protects CMs during ED through activation of autophagy, and mTORC1 may represent therapeutic targets to reduce myocardial damage during ischemia, particularly in obese patients.
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