• Publications
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Changes in Urinary Bladder Neurotrophic Factor mRNA and NGF Protein Following Urinary Bladder Dysfunction
  • M. Vizzard
  • Medicine
  • Experimental Neurology
  • 31 January 2000
Spinal cord injury and cyclophosphamide-induced cystitis dramatically alter lower urinary tract function and produce neurochemical, electrophysiological, and anatomical changes that may contribute toExpand
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Developmental and injury induced plasticity in the micturition reflex pathway
The storage and periodic elimination of urine are dependent upon neural circuits in the brain and spinal cord that co-ordinate the activity of the urinary bladder, the urethra and the striatedExpand
  • 195
  • 11
Alterations in neuropeptide expression in lumbosacral bladder pathways following chronic cystitis
  • M. Vizzard
  • Medicine
  • Journal of Chemical Neuroanatomy
  • 1 March 2001
These studies examined changes in the expression of calcitonin gene-related peptide (CGRP) and substance P (SP) in lumbosacral (L6-S1) micturition reflex pathways, following chronic cystitis inducedExpand
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  • 10
Overexpression of NGF in mouse urothelium leads to neuronal hyperinnervation, pelvic sensitivity, and changes in urinary bladder function.
NGF has been suggested to play a role in urinary bladder dysfunction by mediating inflammation, as well as morphological and functional changes, in sensory and sympathetic neurons innervating theExpand
  • 143
  • 8
  • Open Access
Localization of NADPH diaphorase in the lumbosacral spinal cord and dorsal root ganglia of the cat
The distribution of NADPH‐d activity in the spinal cord and dorsal root ganglia of the cat was studied to evaluate the role of nitric oxide in lumbosacral afferent and spinal autonomic pathways. AtExpand
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COX-2 and prostanoid expression in micturition pathways after cyclophosphamide-induced cystitis in the rat.
The purpose of this study was to determine the role of cyclooxygenase-2 (COX-2) and its metabolites in lower urinary tract function after induction of acute (4 h), intermediate (48 h), or chronic (10Expand
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  • 7
  • Open Access
Cyclophosphamide induced cystitis alters neurotrophin and receptor tyrosine kinase expression in pelvic ganglia and bladder.
PURPOSE We examined neurotrophin and receptor tyrosine kinase (Trk) expression in the bladder and major pelvic ganglia (MPG) after cyclophosphamide induced cystitis in rats. MATERIALS AND METHODSExpand
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  • 7
Role of p75NTR in female rat urinary bladder with cyclophosphamide-induced cystitis.
Previous studies demonstrated changes in urinary bladder neurotrophin content and upregulation of neurotrophin receptors, TrkA and the p75 neurotrophin receptor (p75(NTR)), in micturition reflexExpand
  • 49
  • 7
  • Open Access
Neurochemical plasticity and the role of neurotrophic factors in bladder reflex pathways after spinal cord injury.
  • M. Vizzard
  • Biology, Medicine
  • Progress in brain research
  • 2006
Transection of the spinal cord that interrupts the spinobulbospinal micturition reflex pathway, abolishes voluntary voiding and initially produces an areflexic bladder with complete urinaryExpand
  • 88
  • 6
Changes in urinary bladder cytokine mRNA and protein after cyclophosphamide-induced cystitis.
Cyclophosphamide (CYP)-induced cystitis alters micturition function and produces reorganization of the micturition reflex. This reorganization may involve cytokine expression in the urinary bladder.Expand
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  • 6
  • Open Access