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A prognostic DNA methylation signature for stage I non-small-cell lung cancer.
- Juan Sandoval, J. Méndez-González, +28 authors M. Esteller
- Journal of clinical oncology : official journal…
- 10 November 2013
PURPOSE Non-small-cell lung cancer (NSCLC) is a tumor in which only small improvements in clinical outcome have been achieved. The issue is critical for stage I patients for whom there are no… Expand
Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer
BackgroundOne of the hallmarks of cancer is the disruption of gene expression patterns. Many molecular lesions contribute to this phenotype, and the importance of aberrant DNA methylation profiles is… Expand
Variable maternal methylation overlapping the nc886/vtRNA2-1 locus is locked between hypermethylated repeats and is frequently altered in cancer
Cancer is as much an epigenetic disease as a genetic one; however, the interplay between these two processes is unclear. Recently, it has been shown that a large proportion of DNA methylation… Expand
Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR
Metastasis is responsible for most cancer-related deaths, and, among common tumor types, melanoma is one with great potential to metastasize. Here we study the contribution of epigenetic changes to… Expand
Comprehensive DNA methylation study identifies novel progression-related and prognostic markers for cutaneous melanoma
BackgroundCutaneous melanoma is the deadliest skin cancer, with an increasing incidence and mortality rate. Currently, staging of patients with primary melanoma is performed using histological… Expand
A comprehensive DNA methylation profile of epithelial-to-mesenchymal transition.
Epithelial-to-mesenchymal transition (EMT) is a plastic process in which fully differentiated epithelial cells are converted into poorly differentiated, migratory and invasive mesenchymal cells, and… Expand
Mammalian HP1 Isoforms Have Specific Roles in Heterochromatin Structure and Organization.
- L. Bosch-Presegué, H. Raurell-Vila, +13 authors Alejandro Vaquero
- Biology, Medicine
- Cell reports
- 21 November 2017
HP1 is a structural component of heterochromatin. Mammalian HP1 isoforms HP1α, HP1β, and HP1γ play different roles in genome stability, but their precise role in heterochromatin structure is unclear.… Expand
Aberrant DNA methylation in non-small cell lung cancer-associated fibroblasts
Summary DNA methylation profiling of TAFs reveals global demethylation and a selective impact on the TGF-β pathway. Moreover, it suggests the fibrocyte origin of a fraction of TAFs, and identifies a… Expand
Validation of DNA methylation profiling in formalin-fixed paraffin-embedded samples using the Infinium HumanMethylation450 Microarray
A formalin-fixed paraffin-embedded (FFPE) sample usually yields highly degraded DNA, which limits the use of techniques requiring high-quality DNA, such as Infinium Methylation microarrays. To… Expand
The 5S rDNA gene family in mollusks: characterization of transcriptional regulatory regions, prediction of secondary structures, and long-term evolution, with special attention to Mytilidae mussels.
- M. Vizoso, J. Vierna, A. González-Tizón, A. Martínez-Lage
- Biology, Medicine
- The Journal of heredity
- 1 July 2011
Several reports on the characterization of 5S ribosomal DNA (5S rDNA) in various animal groups have been published to date, but there is a lack of studies analyzing this gene family in a much broader… Expand