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Comparative study of the stability of saxitoxin and neosaxitoxin in acidic solutions and lyophilized samples.
In vitro and in vivo evaluation of paralytic shellfish poisoning toxin potency and the influence of the pH of extraction.
An in vitro quantification method is developed using cultured neurons and the first data evaluating the potencies of PSP toxins after extraction in acidic pHs are provided, indicating that the toxicity of the sample increases in acidic conditions.
Cytoskeletal disruption is the key factor that triggers apoptosis in okadaic acid-treated neuroblastoma cells
Results demonstrate that collapse of mitochondrial membrane potential is accessory in the execution of apoptosis, which is directly dependent on cytoskeletal changes.
Azaspiracid-1, a potent, nonapoptotic new phycotoxin with several cell targets.
Cell growth inhibition and actin cytoskeleton disorganization induced by azaspiracid-1 structure-activity studies.
Azaspiracid-1 (AZA-1) is a marine toxin discovered 10 years ago. Since then, toxicologic studies have demonstrated that AZA-1 targets several organs in vivo, including the intestine, lymphoid…
Azaspiracid-4 inhibits Ca2+ entry by stored operated channels in human T lymphocytes.
Actin cytoskeleton of rabbit intestinal cells is a target for potent marine phycotoxins
- I. Ares, M. Louzao, M. Vieytes, T. Yasumoto, L. Botana
- BiologyJournal of Experimental Biology
- 15 November 2005
The data show that pectenotoxin-6, maitotoxin, palytoxin and ostreocin-D cause a significant reduction in the actin cytoskeleton, and this results identify the cytos skeleton as an early target for the toxic effect of those toxins.
Study of cytoskeletal changes induced by okadaic acid in BE(2)-M17 cells by means of a quantitative fluorimetric microplate assay.
Yessotoxin Induces Er-Stress Followed By Autophagic Cell Death In Glioma Cells Mediated By mTOR and BNIP3.