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YY1-Binding Sites Provide Central Switch Functions in the PARP-1 Gene Expression Network
Evidence is presented for the involvement of the interplay between transcription factor Yin Yang 1 (YY1) and poly(ADP-ribose) polymerase-1 (PARP-1) in the regulation of mouse PARP-1 gene (muPARP-1)Expand
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The greatest part of nuclear C/EBPβ (a major 35kD protein, 30 and 38kD isoforms) was observed to partition with the nuclear matrix. Cross‐linking experiments with formaldehyde suggested that theExpand
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PARP-1 expression in the mouse is controlled by an autoregulatory loop: PARP-1 binding to an upstream S/MAR element and to a novel recognition motif in its promoter suppresses transcription.
This work identifies central components of a feedback mechanism for the expression of mouse poly(ADP-ribose) polymerase-1 (PARP-1). Using the stress-induced duplex destabilization algorithm, multipleExpand
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Relationship between genome and epigenome - challenges and requirements for future research
Understanding the links between genetic, epigenetic and non-genetic factors throughout the lifespan and across generations and their role in disease susceptibility and disease progression offerExpand
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Identification of Nuclear Matrix and Associated Proteins that Bind the Haptoglobin Gene Cis‐Element
To identify the major nuclear matrix proteins that bind to the rat haptoglobin gene cis‐element, we isolated a soluble nuclear matrix protein fraction and analysed it by gel retardation. Two majorExpand
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New Insights into the Epigenetic Activities of Natural Compounds
Background: With their varied pharmacophores, natural products are interesting tools to open the drug discovery pipeline. Several plant secondary metabolites are components of the human diet and haveExpand
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Biochemical indicators and biomarkers in chub (Squalius cephalus L.) from the Sava River.
Biochemical indicators and biomarkers were analyzed in the liver and gills of chub caught in three localities along the Sava River exposed to different environmental impacts. Sampling sites were:Expand
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Chlamydia trachomatis Infection Is Associated with E-Cadherin Promoter Methylation, Downregulation of E-Cadherin Expression, and Increased Expression of Fibronectin and α-SMA—Implications for
Chlamydia trachomatis (Ct) can induce scarring disease of the ocular mucosa, known as trachoma, the most common infectious cause of blindness worldwide. We hypothesized that epithelial-mesenchymalExpand
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Binding of a 23 kD endonuclease to the rat liver nuclear matrix.
In a previous paper we have described a 23 kD nuclear endonuclease (p23) that was mostly found to exist in a state of association with the isolated rat hepatocyte nuclear matrix. To investigate theExpand
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Can we use the epigenetic bioactivity of caloric restriction and phytochemicals to promote healthy ageing
In 2011, the Centers for Disease Control and Prevention reported that half of Americans are using food supplements, intended to provide them with nutrients that they believe they consume inExpand
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